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CompletedNCT02261025Updated Oct 23, 2014

The Effect Of Aspirin On Survival in in Patients Undergoing Chronic Hemodialysis

An interventional study of acetylsalicylic acid in Hemodialysis, sponsored by Shanghai Jiao Tong University School of Medicine. Completed. Open to participants aged 18 Years to 85 Years. Per ClinicalTrials.gov, last updated 2014-10-23.

Sponsored by Shanghai Jiao Tong University School of Medicine · Not applicable, Interventional, and Prevention

Phase
Not applicable
Study type
Interventional
Enrollment
410
Allocation
Non-randomized
Ages
18 Years to 85 Years
Sex
All
01

Study summary

The aim of present study is to examine the effect of low-dose aspirin on the incidence of cardiovascular events and mortality in patients undergoing chronic hemodialysis.

Read the detailed description

This study prospectively evaluate the impacts of low dose aspirin on survival and cardio-cerebral vascular events in a large cohort of Chinese patients undergoing chronic hemodialysis. Between January 2008, consecutive patients with hemodialysis with aspirin were enrolled.We examine the association of aspirin with all-cause mortality in patients matched by propensity scores using the Kaplan-Meier method and Cox models in "intention-to-treat" analyses.The secondary endpoint was rate of cardio-cerebral events.

02

Conditions studied

  • Hemodialysis

Keywords

  • aspirin
03

In context

Lead sponsor

Shanghai Jiao Tong University School of Medicine is the lead sponsor of 358 studies on the registry; 104 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 85 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

All patients aged 18 to 85, undergoing chronic hemodialysis, who have none of the following exclusion criteria.

Exclusion criteria

Exclusion Criteria:

History of gastric or duodenal ulcers Known allergy to aspirin or other NSAIDs

-

05

Study design

Phase
Not applicable
Primary purpose
Prevention
Allocation
Non-randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
410 participants (actual)

Study arms

  • Experimental
    Aspirin group

    Aspirin 75-100mg,per day,oral

    Drug: acetylsalicylic acid

  • No intervention
    non-aspirin group

    No interventions

Interventions

  • Drugacetylsalicylic acid

    75-100mg,per day

    Also known as: Aspirin

06

What researchers measure

Primary outcomes

  1. survival rate

    Time frame: 5 years

Secondary outcomes

  1. cardio-cerebral event

    Time frame: 5 years

07

Study locations

No study locations are listed for this record.

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References and documents

Publications

  • Liu J, Pan Y, Chen L, Qiao QY, Wang J, Pan LH, Gu YH, Gu HF, Fu SK, Jin HM. Low-dose aspirin for prevention of cardiovascular disease in patients on hemodialysis: A 5-y prospective cohort study. Hemodial Int. 2016 Oct;20(4):548-557. doi: 10.1111/hdi.12409. Epub 2016 Mar 1. PubMed 26932276 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 23, 2014, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT02261025
Lead sponsor
Shanghai Jiao Tong University School of Medicine
Responsible party
Hui Min Jin (Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University School of Medicine) — Principal investigator
First posted
Oct 9, 2014
Start date
Jan 2008
Primary completion
Sep 2014
Completion
Sep 2014
Last update
Oct 23, 2014

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2014. You cannot join it, but the record below documents what was studied.

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