An observational study in Off Pump Coronary Artery Bypass Graft, sponsored by Samsung Medical Center. Completed at 1 site in Korea, Republic of. Open to participants aged 20 Years and older. Per ClinicalTrials.gov, last updated 2014-08-21.
Sponsored by Samsung Medical Center · Observational
Off pump coronary artery bypass graft (OPCAB) still requires myocardial protection owing to intermittent regional ischemic episode. The investigators retrospectively evaluated the cardioprotective and clinical outcomes of propofol versus isoflurane anesthesia in patients undergoing OPCAB.
Several experimental and clinical researches have suggested that volatile anesthetics may reduce mortality in cardiac surgery owing to its preconditioning induced cardioprotective effect. Off-pump coronary artery bypass graft (OPCAB) surgery still requires cardioprotective strategies due to coronary hypoperfusion during anastomosis. The aim of this study was to evaluate the possible cardioprotective effect and clinical outcomes of propofol versus isoflurane anesthesia in patients undergoing OPCAB using propensity matching.
Samsung Medical Center is the lead sponsor of 980 studies on the registry; 146 are open to participants now.
Of its 7 completed or terminated interventional studies of FDA-regulated products, 1 (14%) have results posted.
Counted across the registry records on this site, refreshed daily.
patients underwent OPCAB from January, 2010 to December, 2012
Exclusion Criteria:
Isoflurane inhalational anesthesia during OPCAB
Drug: Isoflurane
Total intravenous anesthesia with propofol during OPCAB
Comparison between isoflurane and propofol, Retrospective study
Also known as: inhalational anesthetics
CK-MB, CRP
Comparison of CK-MB and CRP values between propofol and isoflurane groups on postoperative day, POD1 and POD 2
Time frame: Change from preoperative value in CK-MR and CRP at Postoperative day(POD), POD 1 and 2
Clinical adverse outcomes
clinical adverse outcomes until postoperative 1 year
Time frame: until 1 year after OPCAB
Cardioprotection and clinical adverse outcomes in diabetic patients
primary and secondary outcome analysis in diabetic patients
Time frame: POD, POD 1, POD 2, one month, one year
This study is completed, as verified in Aug 2014. You cannot join it, but the record below documents what was studied.
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Samsung Medical Center