An interventional study of Casein Protein and Non-caloric placebo in Obesity, sponsored by Florida State University. Completed at 1 site in United States. Open to male participants aged 18 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2015-08-13.
Sponsored by Florida State University · Not applicable, Interventional, and Treatment
Single macronutrients will be consumed before sleep by obese men. Overnight lipolysis will be measured with the microdialysis technique by measuring glycerol concentration and blood flow in abdominal adipose tissue. Morning fat oxidation will be measured with indirect calorimetry.
The investigators hypothesize that carbohydrate intake will blunt the overnight lipolysis rate compared to casein protein and a non-caloric placebo. The investigators also hypothesize that casein and placebo will not be significantly different from each other in terms of overnight lipolysis.
6,296 studies on the registry are indexed under Obesity; 1,692 are open to participants now.
This study's enrollment of 12 is below the median of 78 across 4,878 interventional studies indexed under Obesity.
Browse Obesity studies →Florida State University is the lead sponsor of 241 studies on the registry; 46 are open to participants now.
Of its 15 completed or terminated interventional studies of FDA-regulated products, 9 (60%) have results posted.
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Exclusion Criteria:
Casein protein (30g) will be consumed as the last food/caloric beverage and within 30 minute of sleep
Other: Casein Protein
The non-caloric placebo beverage will will be consumed as the last food/caloric beverage and within 30 minute of sleep
Other: Non-caloric placebo
The effect of casein protein consumed within 30 minutes of sleep on overnight lipolysis and next morning metabolism and appetite will be examined
The effect of a non-caloric placebo consumed within 30 minutes of sleep on overnight lipolysis and next morning metabolism and appetite will be examined
Lipolysis
Measuring lipolysis using the microdialysis technique. Samples will be collected at various time intervals Vial 1: 30 minute; 2.0 uL/min flow rate Vial 2: 4 hours; 0.3 uL/min flow rate Vial 3: Overnight; 0.3 uL/min flow rate (before taking nighttime supplement) Vial 4: Morning sample #1; 2.0 uL/min flow rate (upon waking) Vial 5: Morning sample #2; 2.0 uL/min flow rate (arrive to lab) Blood flow will be measured using the Ethanol technique
Time frame: Change from day 1 to day 2 to day 3 of testing
Resting Metabolic Rate (RMR)
RMR will be measured with indirect calorimetry using the ventilated hood technique
Time frame: Change from day 1 to day 2 to day 3
Appetite
Appetite will be measured by visual analog scales
Time frame: Change from Baseline to day 1, 2, and 3
Blood hormones
Hormones related to appetite and metabolism will be examined.
Time frame: Change from Baseline to day 1, 2, and 3
This study is completed, as verified in Aug 2015. You cannot join it, but the record below documents what was studied.
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Florida State University