A Phase 4 interventional study of pentazocine and propofol in Induced Abortion and Anesthesia, sponsored by Third Affiliated Hospital of Zhengzhou University. Status unknown. Open to participants aged 20 Years to 35 Years. Per ClinicalTrials.gov, last updated 2014-08-05.
Sponsored by Third Affiliated Hospital of Zhengzhou University · Phase 4, Interventional, and Treatment
To explore the feasibility of different doses of etomidate admixed with propofol in induced abortion: a randomized, double blind controlled trial.
Third Affiliated Hospital of Zhengzhou University is the lead sponsor of 3 studies on the registry; 1 is open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
In group A, propofol (1%) was mixed with etomidate in the ration of 1:1 (volume). The mixture will be injected continuously until the eyelash reflex disappears. During the operation, supplementary mixture will be administered if the patient has spontaneous movement that hampered the conduct of the procedure.
Drug: pentazocine · Drug: propofol · Drug: Etomidate
In group B, propofol (1%) was mixed with etomidate in the ration of 7:5 (volume). The mixture will be injected continuously until the eyelash reflex disappears. During the operation, supplementary mixture will be administered if the patient has spontaneous movement that hampered the conduct of the procedure.
Drug: pentazocine · Drug: propofol · Drug: Etomidate
In group C, propofol (1%) will be injected continuously until the eyelash reflex disappears. During the operation, supplementary propofol will be administered if the patient has spontaneous movement that hampered the conduct of the procedure.
Drug: pentazocine · Drug: propofol
Every patient enrolled in the study will be given 15 mg pentazocine before induction.
Heart rate
Heart rate will be recorded immediately when the patient arrived at the operating room, 2 min, 4 min, 6 min, 8 min and 10 minutes after the the injection of propofol or mixture of propofol and etomidate.
Time frame: From baseline (before the injection of propofol or mixture of propofol and etomidate) to 10 min after the injection
Blood pressure
Blood pressure will be recorded immediately when the patient arrived at the operating room, 2 min, 4 min, 6 min, 8 min and 10 minutes after the the injection of propofol or mixture of propofol and etomidate.
Time frame: From baseline (before the injection of propofol or mixture of propofol and etomidate) to 10 min after the injection
Pulse oxygen saturation
Pulse oxygen saturation will be recorded immediately when the patient arrived at the operating room, 2 min, 4 min, 6 min, 8 min and 10 minutes after the the injection of propofol or mixture of propofol and etomidate.
Time frame: From baseline (before the injection of propofol or mixture of propofol and etomidate) to 10 min after the injection
Efficacy of anesthesia
The following point-in-time will be recorded to calculated the period from the injection of propofol or mixture of propofol and etomidate: disappearance of eyelash reflex, injection of supplementary propofol or mixture of propofol and etomidate, awaking, obeying commands, discharge. Anesthesia time was defined as the period from disappearance of eyelash reflex to awaking.
Time frame: from baseline to discharge from the hospital, expected to no more than 1 hour
Dose of propofol or mixture of propofol and etomidate
Time frame: from the injection of propofol or mixture of propofol and etomidate to the last supplement of hypnotic agents, expected to be no more than 5 min
Use of specific medications
Time frame: from the injection of propofol or mixture of propofol and etomidte to discharge from the hospital, expected to no more than 1 hour
Aldrete score
Time frame: 10 min after the opration
Verbal rating scales of uterine contraction
Verbal rating scales of uterine contraction should be recorded at 5 min, 15 min after the operation and before discharge from the hospital
Time frame: from 5 min after the operation to discharge from the hospital, expected to be no more than 1 hour
Satisfaction degree of the patient, the surgeon and the anesthetist
Satisfaction degree will be rated as excellent, good and poor based on a scale of 1 to 10. Excellent is 8 to 10, good is 5 to 7 and poor is 1 to 4.
Time frame: 10 min before discharge from the hospital
No study locations are listed for this record.
This study is status unknown, as verified in Aug 2014. You cannot join it, but the record below documents what was studied.
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Third Affiliated Hospital of Zhengzhou University