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CompletedNCT02186990Updated Aug 13, 2014

Comparison of Etomidate, Propofol and Etomidate-propofol Combination in Terms of Effects on Haemodynamic Response to Intubation

A Phase 4 interventional study of propofol and etomidate in Induction of Anaesthesia, sponsored by T.C. ORDU ÜNİVERSİTESİ. Completed at 1 site in Turkey. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2014-08-13.

Sponsored by T.C. ORDU ÜNİVERSİTESİ · Phase 4, Interventional, and Prevention

Phase
Phase 4
Study type
Interventional
Enrollment
90
Allocation
Randomized
Ages
18 Years to 65 Years
Sex
All
01

Study summary

The purpose of this study is to evaluate the effect of propofol, etomidate and propofol-etomidate combination on hemodynamic responses during laryngoscopy and tracheal intubation and assess the adverse effect related to this drugs.

02

Conditions studied

  • Induction of Anaesthesia
03

In context

Lead sponsor

T.C. ORDU ÜNİVERSİTESİ is the lead sponsor of 87 studies on the registry; 12 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • between 18 - 65 age
  • ASA I - II status
  • elective surgery

Exclusion criteria

Exclusion Criteria:

  • emergency surgery
  • pregnancy
  • alcohol and drug abuse
  • HT and cardiovascular disease
  • BMI > 25 kg/m2
  • hypersensitivity against study drug
  • sedative drug use in last month
  • difficult intubation
05

Study design

Phase
Phase 4
Primary purpose
Prevention
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Outcomes assessor)
Enrollment
90 participants (actual)

Study arms

  • Active comparator
    propofol

    Drug: etomidate-propofol

  • Active comparator
    etomidate

    Drug: etomidate

  • Active comparator
    propofol-etomidate

    Drug: propofol

Interventions

  • Drugpropofol

    2,5 mg/kg

  • Drugetomidate

    0,3 mg/kg

  • Drugetomidate-propofol

    0,15 mg/kg etomidate + 1,25 mg/kg propofol

06

What researchers measure

Primary outcomes

  1. haemodynamic values

    e.g., heart rate, blood pressure (mean arterial pressure)

    Time frame: in ten minutes after intubation

Secondary outcomes

  1. adverse effect of study drugs

    e.g. myoclonus, injection pain, allergy, skin rash

    Time frame: within in 30 minutes drug administration

07

Study locations

1 site
  • Anesthesiology and Reanimation Dept. Ordu University Training and Research Hospital
    Altınordu, Ordu 52100, Turkey
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 13, 2014, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT02186990
Lead sponsor
T.C. ORDU ÜNİVERSİTESİ
Responsible party
özgür yağan (MD, T.C. ORDU ÜNİVERSİTESİ) — Principal investigator
First posted
Jul 10, 2014
Start date
May 2014
Primary completion
Aug 2014
Last update
Aug 13, 2014
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Aug 2014. You cannot join it, but the record below documents what was studied.

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