An interventional study of Exercise Energy Expenditure 300 kcal/day and Exercise Energy Expenditure 600 kcal/day in Overweight and Obese, sponsored by USDA Grand Forks Human Nutrition Research Center. Completed at 1 site in United States. Open to participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-04-11.
Sponsored by USDA Grand Forks Human Nutrition Research Center · Not applicable, Interventional, and Other
The purpose of this study is to research the effects of exercise on calories eaten and expended. The investigator expects to find out whether subjects change their eating and activity behaviors when starting an exercise program.
3,670 studies on the registry are indexed under Overweight; 849 are open to participants now.
This study's enrollment of 29 is below the median of 73 across 3,175 interventional studies indexed under Overweight.
Browse Overweight studies →USDA Grand Forks Human Nutrition Research Center is the lead sponsor of 58 studies on the registry; 3 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Subjects will be randomly assigned to this group and will exercise energy expenditure of 300 kcal/day.
Other: Exercise Energy Expenditure 300 kcal/day
Subjects will be randomly assigned to this group and will exercise energy expenditure of 600 kcal/day.
Other: Exercise Energy Expenditure 600 kcal/day
Negative Energy Balance as assessed by changes in adipose tissue
Whether participants were able to maintain a negative energy balance will be assessed by pre-post changes in stored adipose tissue, as assessed by a dual-energy x-ray absorptiometry scan (DEXA).
Time frame: End Training (weeks 10-12)
Change in relative reinforcing value (RRV) of food
RRV of food will be assessed by evaluating the number of responses (mouse button presses) a participant is willing to complete to gain access to food or an alternative sedentary activity.
Time frame: Pre-intervention (week 0) and End Training (weeks 10-12)
Average daily calories consumed as assessed by dietary recall
On two weekdays and one weekend day, participants will fill out the Automated Self-Administered 24-Hour Dietary Recall (ASA24) to estimate dietary intake (total energy, grams carbohydrates, fat, protein, alcohol).
Time frame: Pre-intervention (week 0) and End Training (weeks 10-12)
Pre-post intervention changes in Ghrelin plasma levels
Participants will provide a fasting blood sample collected in ethylenediaminetetraacetic acid (EDTA)-coated and serum tubes. Changes in acylated Ghrelin will be measured via enzyme-linked immunosorbent assay (ELISA).
Time frame: Pre-intervention (week 0) and End Training (weeks 10-12)
Pre-post intervention changes in glucagon-like peptide 1 (GLP-1) plasma levels
Participants will provide a fasting blood sample collected in EDTA-coated and serum tubes. Changes in GLP-1 concentrations will be measured via ELISA.
Time frame: Pre-intervention (week 0) and End Training (weeks 10-12)
Pre-post intervention changes in Ghrelin concentrations
Participants will provide a fasting blood sample collected in EDTA-coated and serum tubes. Changes in Ghrelin concentrations will be measured via ELISA.
Time frame: Pre-intervention (week 0) and End Training (weeks 10-12)
Pre-post intervention changes in irisin concentrations
Participants will provide a fasting blood sample collected in EDTA-coated and serum tubes. Changes in irisin concentrations will be measured via ELISA.
Time frame: Pre-intervention (week 0) and End Training (weeks 10-12)
Pre-post intervention changes in myostatin plasma levels
Participants will provide a fasting blood sample collected in EDTA-coated and serum tubes. Changes in myostatin levels will be measured via ELISA.
Time frame: Pre-intervention (week 0) and End Training (weeks 10-12)
Change in relative reinforcing value (RRV) of physical activity
RRV of physical activity will be assessed by evaluating the number of responses (mouse button presses) a subject is willing to complete to gain access to physical activity or a sedentary alternative.
Time frame: Pre-intervention (week 0) and End Training (weeks 10-12)
Change in minutes of sedentary behavior, as assessed by activity tracker
Minutes of sedentary behavior (non-exercise activity) will be assessed by having participants wear an Actigraph accelerometer for 7 days (minimum 10 hours per day) on the right hip.
Time frame: Pre-intervention (week 0) and End Training (weeks 10-12)
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Apr 2025. You cannot join it, but the record below documents what was studied.
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USDA Grand Forks Human Nutrition Research Center