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CompletedNCT02128399Updated May 1, 2014

Antimicrobial Stewardship Reduces MDRO Isolates in Critically Ill Patients

An observational study in Sepsis, sponsored by Jianfeng Xie. Completed. Per ClinicalTrials.gov, last updated 2014-05-01.

Sponsored by Jianfeng Xie · Observational

Study type
Observational
Time perspective
Prospective
Enrollment
978
Sex
All
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Study summary

Antimicrobial exposure is known to reduce the selection for various drug-resistant organisms. Numerous studies have demonstrated the association between antimicrobial use and MDR bacteria detection. However, to the investigators knowledge, there is few data to support the concept that reducing antibiotic use actually leads to improvements in antibiotic susceptibilities. Moreover, antimicrobial stewardship was demonstrated to reduce MDRO and was strongly recommended in clinics. As the investigators know, antimicrobial overuse, which occurs commonly in China, induces a severe antibacterial resistance. China's Ministry of Health (MOH) has established a policy about the antimicrobial stewardship. To date, the investigators do not have published documentation the effects of this policy on multidrug-resistant organism (MDRO) in critically ill patients.

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Conditions studied

  • Sepsis

Keywords

  • antimicrobial stewardship
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In context

Lead sponsor

Jianfeng Xie is the lead sponsor of 12 studies on the registry; 2 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

patients who admitted into intensive care unit

Inclusion criteria

  • Patients hospitalized in the ICU

Exclusion criteria

Exclusion Criteria:

  • Patients who were readmitted to the ICU during a single hospital stay
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Study design

Time perspective
Prospective
Enrollment
978 participants (actual)
Patient registry
No

Groups and cohorts

  • patients before and after intervetion
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What researchers measure

Primary outcomes

  1. The number of participates infection or colonization with MDRO in critically ill patients at ICU admission and discharge as a measure of effect of antimicrobial stewardship

    MDRO isolation from inclusion to the date of discharge of hospital, access up to 90 days

    Time frame: up to 90 days

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Study locations

No study locations are listed for this record.

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References and documents

Publications

  • Ma X, Xie J, Yang Y, Guo F, Gao Z, Shao H, Huang Y, Yang C, Qiu H. Antimicrobial stewardship of Chinese ministry of health reduces multidrug-resistant organism isolates in critically ill patients: a pre-post study from a single center. BMC Infect Dis. 2016 Nov 25;16(1):704. doi: 10.1186/s12879-016-2051-8. PubMed 27887595 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 1, 2014, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT02128399
Lead sponsor
Jianfeng Xie
Responsible party
Jianfeng Xie (doctor of department of critical care medicine, Southeast University, China) — Sponsor-investigator
First posted
May 1, 2014
Start date
Jun 2012
Primary completion
May 2013
Completion
Dec 2013
Last update
May 1, 2014
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jul 2012. You cannot join it, but the record below documents what was studied.

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