An interventional study of Glucose ingestion and Sucrose ingestion in Liver and Muscle Glycogen Use During Exercise., sponsored by Javier Gonzalez, PhD. Completed at 1 site in United Kingdom. Open to male participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2015-08-07.
Sponsored by Javier Gonzalez, PhD · Not applicable, Interventional, and Basic science
Carbohydrate is stored in the body as glycogen, which is mainly found in the liver and muscle. During endurance exercise, muscle glycogen is used as fuel for the working muscles and liver glycogen is broken down to provide glucose to maintain blood glucose (sugar) levels. Both liver and muscle glycogen are important for the ability to perform intense/prolonged endurance exercise. Therefore, nutritional strategies which can maximise the availability of glycogen in muscle and liver can benefit endurance exercise capacity.
The carbohydrates typically found in sports drinks are glucose and sometimes fructose. If glucose only is ingested during exercise, then the maximum rate at which can be absorbed from the intestine into the blood stream is \~1 g/min. However, if different sources of carbohydrate (fructose) are used, which are absorbed through a different pathway, absorption of carbohydrate can be up to \~1.8 g/min. With more carbohydrate available as a fuel, this translates into an improvement in performance.
Sucrose is a naturally occurring sugar that is made up of a single glucose and single fructose molecule. Therefore, theoretically, this can use the two different pathways of absorption and also maximise carbohydrate delivery. It is not yet known however, what impact this has on our liver and muscle glycogen stores during exercise. Therefore the aim of this study is to assess whether sucrose ingestion influences liver and muscle glycogen depletion during endurance exercise.
This is the only study on the registry with Javier Gonzalez, PhD as lead sponsor.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Glucose ingestion during exercise at a rate of 1.8 g/min.
Dietary Supplement: Glucose ingestion
Sucrose ingestion during exercise at a rate of 1.8 g/min.
Dietary Supplement: Sucrose ingestion
Glucose ingestion during exercise at 1.8 g/min
Sucrose ingestion during exercise at 1.8 g/min
Change in liver glycogen concentration
The change in liver glycogen concentration will be determined pre-to-post 3 h of exercise using 13C magnetic resonance spectroscopy.
Time frame: 3 hours
Plasma glucose concentration.
Plasma glucose concentrations will be determined every 30 min during 3 h of exercise.
Time frame: 3 hours
Plasma lactate concentration
Plasma lactate concentrations will be determined every 30 min during 3 h of exercise.
Time frame: 3 hours
Plasma non-esterified fatty acid concentration
Plasma non-esterified fatty acid concentrations will be determined every 30 min during 3 h of exercise.
Time frame: 3 hours
Indirect calorimetry
Measurements of oxygen consumption, carbon dioxide production and respiratory exchange ratio through indirect calorimetry measured every 30 minutes during exercise.
Time frame: 3 hours
Muscle glycogen concentration
The change in muscle glycogen concentration will be determined pre-to-post 3 h of exercise using 13C magnetic resonance spectroscopy.
Time frame: 3 hours
Change in intramyocellular lipid concentration
The change in intramyocellular lipid concentration will be determined pre-to-post 3 h of exercise using 1H magnetic resonance spectroscopy.
Time frame: 3 hours
This study is completed, as verified in Aug 2015. You cannot join it, but the record below documents what was studied.
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