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CompletedNCT02109796tDCS(HE)Updated Nov 14, 2017

Effects of tDCS on Quadriceps Strength After Stroke

An interventional study of transcranial Direct current stimulation in Stroke, sponsored by Centre d'Investigation Clinique et Technologique 805. Completed at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2017-11-14.

Sponsored by Centre d'Investigation Clinique et Technologique 805 · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
14
Allocation
Randomized
Ages
18 Years and older
Sex
All
01

Study summary

Previous studies show that one session of tDCS allow to improve muscle strength in hemiparetic patients in anodal condition. We test a new electrods configuration : a anodale stimulation opposite to the cortical representation area of the injured hemisphere and a simultaneous stimulation opposite to the homonyme the cortical representation area of the healthy hemisphere. This approach seems to be the best relevant electrods configuration in order to restore the inter-hemispheric balance.

We hypothesis that one session of tDCS with this electrods configuration allow to improve paretic quadriceps strength in hemiparetic patients after stroke.

02

Conditions studied

  • Stroke

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Keywords

  • tDCS
  • Stroke
  • Force
  • Spasticity
  • Gait
  • EMG
  • Isokinetic
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In context

Stroke

7,286 studies on the registry are indexed under Stroke; 2,007 are open to participants now.

This study's enrollment of 14 is below the median of 50 across 5,369 interventional studies indexed under Stroke.

Browse Stroke studies →

Lead sponsor

Centre d'Investigation Clinique et Technologique 805 is the lead sponsor of 74 studies on the registry; 2 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • written consent
  • hemiparetic patient after stroke in chronic phase (> 6 months)
  • capacity to walk with or without technical assistance
  • following rehabilitation program for lower limbs

Exclusion criteria

Exclusion Criteria:

  • patient with bilateral brain lesion, cerebellar syndrom, and apraxia and/or aphasia
  • previous orthopedic surgery in paretic lower limb (\<6 moths)
  • usual tDCS contraindications
  • pregnant woman
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Crossover assignment
Masking
Single (Participant)
Enrollment
14 participants (actual)

Study arms

  • Experimental
    hemiplegic patient

    anodal transcranial direct current stimulation

    Device: transcranial Direct current stimulation

  • Sham comparator
    patient control

    Sham transcranial direct current stimulation

    Device: transcranial Direct current stimulation

Interventions

  • Devicetranscranial Direct current stimulation
06

What researchers measure

Primary outcomes

  1. maximum voluntary isometric strength of knee extensors

    The maximum voluntary isometric strength of paretic knee extensors will be evaluated with a isokinetic dynamometer, which measure peak torque.

    Time frame: 2 hours

Secondary outcomes

  1. Resistive peak torque during passive knee flexion

    Time frame: 2h

  2. Angle related to the resistive peak torque generation of the knee extensors

    Time frame: 2h

  3. Amplitude of the interpolation twitch

    Time frame: 2h

  4. EMG activation of the knee flexors and extensors during the strength evaluations (active and passive)

    Time frame: 2h

  5. Functional evaluation of the gait performance and balance

    Time frame: 2h

07

Study locations

1 site
  • Raymond Poincare Hospital
    Garches, 92380, France
08

References and documents

Publications

  • Elsner B, Kugler J, Pohl M, Mehrholz J. Transcranial direct current stimulation (tDCS) for improving activities of daily living, and physical and cognitive functioning, in people after stroke. Cochrane Database Syst Rev. 2020 Nov 11;11(11):CD009645. doi: 10.1002/14651858.CD009645.pub4. PubMed 33175411 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Nov 14, 2017, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT02109796
Lead sponsor
Centre d'Investigation Clinique et Technologique 805
Collaborators
Fondation Garches
Responsible party
Sponsor
First posted
Apr 10, 2014
Start date
Feb 19, 2015
Primary completion
Nov 28, 2016
Completion
Apr 30, 2017
Last update
Nov 14, 2017

Study contacts

Roche Nicolas, MD PH
principal investigator · Raymond Poincaré Hospital
Bensmail Djamel, MD PH
principal investigator · Raymond Poincare Hospital

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Nov 2017. You cannot join it, but the record below documents what was studied.

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