A Phase 2 interventional study of Propranolol in Renal Angiomyolipomas and Tuberous Sclerosis, sponsored by University Hospital, Bordeaux. Terminated at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-06-24.
Sponsored by University Hospital, Bordeaux · Phase 2, Interventional, and Treatment
Treatment of angiomyolipomas is based on invasive techniques such as surgery or embolization. Development of anti-angiogenic therapies is a major and growing field of research in hypervascularized tumors. Angiomyolipomas have been shown to regress after prolonged treatment with mTOR inhibitors (Sirolimus), but with a large proportion of secondary effects. We showed recently that beta-blockers were able to induce regression of infantile hemagiomas. Consequently, we looked for and found, histologically, in a few cases of angiomyolipomas the presence of beta2 receptors.
The aim of the study is to estimate if beta-blockers could induce regression or stabilization of renal angiomyolipomas in tuberous sclerosis in a pilot study.
115 studies on the registry are indexed under Tuberous Sclerosis; 27 are open to participants now.
This study's enrollment of 2 is below the median of 52 across 73 interventional studies indexed under Tuberous Sclerosis.
Browse Tuberous Sclerosis studies →University Hospital, Bordeaux is the lead sponsor of 806 studies on the registry; 197 are open to participants now.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A biopsy takes a small piece of tissue to examine. “Archival tissue” is a sample already taken, for example at diagnosis, and kept by the hospital.
Whether a stored sample will do depends on when it was taken, how much there is and what the study needs. Ask whether the study accepts your stored sample or needs a new biopsy.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Biopsy and archival tissue
A biopsy takes a small piece of tissue to examine. “Archival tissue” is a sample already taken, for example at diagnosis, and kept by the hospital.
Whether a stored sample will do depends on when it was taken, how much there is and what the study needs. Ask whether the study accepts your stored sample or needs a new biopsy.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Drug: Propranolol
Evolution of angiomyolipomas volume
Stabilization or even regression of angiomyolipomas volume after 6 months and 1 year of treatment with a quantification of the vascular component.
Time frame: 6 months and 1 year after inclusion
Renal function evolution
Improvement of renal function after 6 months and 1 year of treatment
Time frame: 6 months and 1 year after inclusion
Effect on the potential haemorraghic transformation
Haemorraghic transformation of angiomyolipomas is diagnosed by Scanner or MRI.
Time frame: 6 months and 1 year after inclusion
Improvement of the quality of life
Th evolution of the quality of life is assessed by an EVA scale and by QOL scale.
Time frame: 6 months and 1 year after inclusion.
Effect on face angiofibromas
Evolution of the face angiofibromas by a dermatologic assessment.
Time frame: 6 months and 1 year after inclusion
This study is terminated, as verified in Jan 2018. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Propranolol
University Hospital, Bordeaux →