An interventional study of vegetables from fresh or recycled water and receives vegetables from fresh water or recycled waste water farms in Healthy Individuals, sponsored by Hadassah Medical Organization. Completed at 1 site in Israel. Open to participants aged 18 Years to 68 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-04-10.
Sponsored by Hadassah Medical Organization · Not applicable, Interventional, and Other
Over 60% of crops in Israel are grown in recycled treated waste water. This study aims to determine whether minute quantities of drugs such as Carbamazepine can be found in individuals who ingest vegetables grown in waste water.
40 healthy volunteers will undergo a food frequency questionnaire and ask to undergo a daily food diary.They will also be asked about drug exposure.
At baseline they will provide a urine and hair sample to determine presence of pharmaceuticals.
They will then undergo a crossover trial wih one week exposure to vegetables grown in recycled waste water or fresh water, with a three day wash out period. Participants will be asked to ingest a minimal amount of lettuce, carrots, peppers, tomatoes and lettuce during the study period.
During this period questionnaires will continue and urine samples will be collected every three days. The first compound to be tested will be carbamazepine, as it is stable in water.
It is important to note that vegetables provided to the participants are available in regular grocery stores.
Participants will be asked to drink bottled water throughout the study period . A sample of their home drinking water will also be tested for Carbamazepine as will a sample of the vegetables they consume.
Hadassah Medical Organization is the lead sponsor of 659 studies on the registry; 54 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
receives vegetables from freshwater farms
Other: vegetables from fresh or recycled water · Other: receives vegetables from fresh water or recycled waste water farms
receives vegetables from farms using recycled wastewater irrigation
Other: vegetables from fresh or recycled water · Other: receives vegetables from fresh water or recycled waste water farms
mean urine carbamazepine level in parts per billion
Urine will be tested on days -3,0,4,8
Time frame: two weeks
This study is completed, as verified in Aug 2015. You cannot join it, but the record below documents what was studied.
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Hadassah Medical Organization