An interventional study of magnesium sulfate 30 mg/kg and saline in Observation of Neuromuscular Block, Intubation Condition and Surgical Condition, sponsored by Seoul National University Hospital. Completed at 1 site in Korea, Republic of. Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2016-04-18.
Sponsored by Seoul National University Hospital · Not applicable, Interventional, and Treatment
This study aims to evaluate effects of magnesium sulfate on onset and duration of low dose rocuronium, intubation condition and surgical condition.
1,327 studies on the registry are indexed under Disease; 596 are open to participants now.
This study's planned enrollment of 84 is close to the median of 80 across 732 interventional studies indexed under Disease.
Browse Disease studies →Seoul National University Hospital is the lead sponsor of 1,860 studies on the registry; 275 are open to participants now.
Of its 12 completed or terminated interventional studies of FDA-regulated products, 2 (17%) have results posted.
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Exclusion Criteria:
pretreatment of saline 100ml and rocuronium 0.6 mg/kg
Drug: saline
pretreatment of saline 100ml and rocuronium 0.45 mg/kg
Drug: saline
pretreatment of magnesium sulfate 30 mg/kg and rocuronium 0.45 mg/kg
Drug: magnesium sulfate 30 mg/kg
Patients in each group received the magnesium sulfate 30 mg/kg for 2 min in 0.9% normal saline (total volume 100 ml) intravenously for 5 min before induction of anesthesia
Patients in each group received 0.9% normal saline (total volume 100 ml) alone intravenously for 5 min before induction of anesthesia
onset time of rocuronium
from injection of rocuronium to T1 suppression more than 95% up to 10 minutes
Time frame: from injection of rocuronium to T1 suppression more than 95% up to 10 minutes
maximal suppression time and duration of rocuronium
Time frame: time from the injection of rocuronium to T1 maximal suppression time and reversal of T1 25% up to 1 hours
intubation condition
We scored intubation condition on the basis of 4 items, laryngoscopy, vocal cord position, moving of limbs, and coughing.
Time frame: intubation condition during induction of anesthesia up to 10 minutes
surgical condition
to score a surgical condition according to 7 point likers scale
Time frame: intraoperative surgical condition
postoperative sore throat
Time frame: postoperative sore throat up to 4 hours
This study is completed, as verified in Jul 2015. You cannot join it, but the record below documents what was studied.
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Seoul National University Hospital