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Status unknownNCT02091544Updated Apr 30, 2020

Etiological Factors, Risk Factors and Early Stages of Chronic Disease in Different Degrees of Childhood Overweight

An observational study in Childhood Obesity, sponsored by Maastricht University Medical Center. Status unknown at 1 site in Netherlands. Open to participants aged Up to 18 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-04-30.

Sponsored by Maastricht University Medical Center · Observational

The sponsor has not verified this record recently (last verified Apr 2020), so the status shown — last known as Recruiting — may be out of date.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
1,000
Ages
Up to 18 Years
Sex
All
01

Study summary

Children and adolescents with overweight and obesity are predisposed to significant health problems. It is known that childhood obesity can adversely affect almost every organ system, and if left untreated, the major impact of childhood overweight is likely to be felt in the next generation of adults.

The aim of " Kijk op overgewicht bij kinderen" is to collect and follow-up longitudinal data from a population of different degrees of children with overweight regarding etiological factors, risk factors and early stages of chronic disease in different degrees of childhood overweight.

Read the detailed description

Furthermore, from april 2020 onwards, a prospective sub study will be conducted. This sub study aims to investigate the changes in lifestyle behaviour of children with overweight or obesity and their families during the COVID-19 pandemic, including the (governmental) measures taken for this, and the effect of obesity and different weight-related risk factors on the host response of these children.

The goal of this sub study is to collect data to enable analyses for future research questions regarding the influence of the COVID-19 on the lifestyle of a child with overweight and their family. Endpoints are for example physical activity, eating behavior, BMI-z score, remote lifestyle coaching, quality of life and parental practices regarding nutrition and physical activity behavior. We will also measure symptoms associated with COVID-19 and the host response that target COVID-19.

02

Conditions studied

  • Childhood Obesity

Keywords

  • overweight
  • obesity
  • children
  • lifestyle intervention
03

In context

Overweight

3,670 studies on the registry are indexed under Overweight; 849 are open to participants now.

This study's planned enrollment of 1,000 is above the median of 150 across 436 observational studies indexed under Overweight.

Browse Overweight studies →

Lead sponsor

Maastricht University Medical Center is the lead sponsor of 835 studies on the registry; 122 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Up to 18 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

overweight or obese children according to the International Obesity Task Force (IOTF) criteria \< 18 years old.

Inclusion criteria

  • Participation in the COACH program
  • Aged till 18 years old (at time of inclusion)
  • Overweight or obesity according to International Obesity Task Force (IOTF) criteria

Exclusion criteria

Exclusion Criteria:

  • None
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
1,000 participants (estimated)
Patient registry
No
Biospecimen retention
Samples with dna

Groups and cohorts

  • Lifestyle intervention

    lifestyle intervention

    Other: Lifestyle intervention

Interventions

  • OtherLifestyle intervention
06

What researchers measure

Primary outcomes

  1. The number of overweight or obese children

    Time frame: approximately 10 years

07

Study locations

1 of 1 sites recruiting
  • Maastricht University Medical Center
    Maastricht, Limburg 6202AZ, Netherlands
    • Anita Vreugdenhil, Dr. · Contact · 0031 (0)43 387 5284
    • Kylie Karnebeek, Drs. · Contact · 0031 (0)43 387 4402
    • Anita Vreugdenhil, Dr. · Principal investigator
    • Jesse Rijks, Drs. · Sub investigator
    • Kylie Karnebeek, Drs. · Sub investigator
    Recruiting
08

References and documents

Publications

  • Lubrecht J, Arayess L, Reijnders D, Hesselink ML, Velde GT, Janse A, von Rosenstiel I, van Mil EGAH, Verweij M, Vreugdenhil ACE. Weight Gain in Children during the COVID-19 Pandemic and the Protective Effect of Lifestyle Intervention in Children with Obesity. Obes Facts. 2022;15(4):600-608. doi: 10.1159/000525298. Epub 2022 May 31. PubMed 35640561 ↗
  • van Dam MJCM, Pottel H, Vreugdenhil ACE. Creatinine-based GFR-estimating equations in children with overweight and obesity. Pediatr Nephrol. 2022 Oct;37(10):2393-2403. doi: 10.1007/s00467-021-05396-y. Epub 2022 Feb 24. PubMed 35211793 ↗
  • Ten Velde G, Plasqui G, Dorenbos E, Winkens B, Vreugdenhil A. Objectively measured physical activity and sedentary time in children with overweight, obesity and morbid obesity: a cross-sectional analysis. BMC Public Health. 2021 Aug 17;21(1):1558. doi: 10.1186/s12889-021-11555-5. PubMed 34404361 ↗
  • Rijks JM, Plat J, Dorenbos E, Penders B, Gerver WM, Vreugdenhil ACE. Association of TSH With Cardiovascular Disease Risk in Overweight and Obese Children During Lifestyle Intervention. J Clin Endocrinol Metab. 2017 Jun 1;102(6):2051-2058. doi: 10.1210/jc.2016-3057. PubMed 28379580 ↗
  • Rijks J, Karnebeek K, van Dijk JW, Dorenbos E, Gerver WJ, Stouthart P, Plat J, Vreugdenhil A. Glycaemic Profiles of Children With Overweight and Obesity in Free-living Conditions in Association With Cardiometabolic Risk. Sci Rep. 2016 Aug 18;6:31892. doi: 10.1038/srep31892. PubMed 27534260 ↗
  • Rijks J, Penders B, Dorenbos E, Straetemans S, Gerver WJ, Vreugdenhil A. Pituitary response to thyrotropin releasing hormone in children with overweight and obesity. Sci Rep. 2016 Aug 3;6:31032. doi: 10.1038/srep31032. PubMed 27485208 ↗

Related links

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 30, 2020, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT02091544
Lead sponsor
Maastricht University Medical Center
Responsible party
Sponsor
First posted
Mar 19, 2014
Start date
Apr 2014
Primary completion
Apr 2023 (estimated)
Completion
Apr 2023 (estimated)
Last update
Apr 30, 2020

Study contacts

Anita Vreugdenhil, Dr
Contact
a.vreugdenhil@mumc.nl
0031 (0)43 387 5284
Kylie Karnebeek, Drs
Contact
0031 (0)43 387 4402
Anita Vreugdenhil, Dr
principal investigator · Maastricht University Medical Center
Luc Zimmermann, Prof.dr.
study chair · Maastricht University Medical Center

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Apr 2020. You cannot join it, but the record below documents what was studied.

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