An interventional study of Ingestion of solution and Rinising of solution in Self-control, Cognitive Performance and Blood Glucose Response, sponsored by University of Leeds. Completed at 1 site in United Kingdom. Open to participants aged 50 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2016-05-12.
Sponsored by University of Leeds · Not applicable, Interventional, and Basic science
The purpose of this study is to examine the effects of ingesting or mouth rinsing a sucrose (carbohydrate) versus a sucralose (carbohydrate-free) drink on self control, cognitive performance, and blood glucose level.
51 studies on the registry are indexed under Self-Control; 15 are open to participants now.
This study's enrollment of 40 is below the median of 72 across 46 interventional studies indexed under Self-Control.
Browse Self-Control studies →University of Leeds is the lead sponsor of 206 studies on the registry; 25 are open to participants now.
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Exclusion Criteria:
A 381g blackcurrant drink (cordial and water) providing 50g of sucrose
Dietary Supplement: Ingestion of solution · Dietary Supplement: Rinising of solution
A 381g blackcurrant drink (cordial and water) providing 0.92g of natural sugars
Dietary Supplement: Ingestion of solution · Dietary Supplement: Rinising of solution
Participants will ingest the solution
Participants rinse the solution in the oral cavity
Capillary blood glucose change from baseline following rinsing or ingesting sucrose or sucralose solutions
Change from baseline in capillary blood glucose (assessed by lancet fingerprick and YSI blood glucose analyser)
Time frame: - 30, -15, - 5, + 5, + 10, + 20, + 30, + 40 minutes relative to rinsing or ingestion of sucrose or sucralose solutions (each separated by 7 days in crossover manner)
Visual verbal learning and memory performance following self-control depletion
Visual verbal learning performance will be assessed by the Visual Verbal Learning Test (Rey, 1964) following a self-control depletion task and ingestion or rinsing of a sucrose or sucralose solution
Time frame: + 35 minutes post ingestion or rinsing of sucrose or sucralose solutions (each separated by 7 days in crossover manner)
Attention switching performance following self-control depletion
Attention switching performance will be assessed by a switch task (Rogers and Monsell, 1995) following a self-control depletion task and ingestion or rinsing of a sucrose or sucralose solution
Time frame: + 20 minutes post ingestion or rinsing of sucrose or sucralose solutions (each separated by 7 days in crossover manner)
Continuous blood glucose change from baseline following rinsing or ingesting sucrose or sucralose solutions
A subgroup of 10 participants recruited into the study will be fitted with a continuous glucose monitoring device (CGMS, iPRO) the day preceding each of the test days to measure continuous interstitial blood glucose levels
Time frame: 24 hours preceding and during ingestion or rinsing of sucrose or sucralose solutions (each separated by 7 days in a crossover manner)
Plan to share: Undecided
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This study is completed, as verified in May 2016. You cannot join it, but the record below documents what was studied.
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