An interventional study of Group Colloid and Cristalloid administration in Mechanical Ventilation Complication and Actual Impaired Fluid Volume, sponsored by Università degli Studi di Ferrara. Status unknown at 1 site in Italy. Open to participants aged 18 Years to 85 Years. Per ClinicalTrials.gov, last updated 2016-11-08.
Sponsored by Università degli Studi di Ferrara · Not applicable, Interventional, and Health services research
The investigators hypothesize that large doses of fluids used during intraoperative could affect lung parenchyma structure and, consequently, gas exchange and respiratory mechanics. The purpose of this study is to evaluate fluids effects on oxygenation, respiratory mechanics, by using two different solutions: crystalloid or colloid.
Inclusion Criteria:
Exclusion Criteria:
Respiratory mechanic parameters (i.e., inspiratory peak pressure, plateau pressure, total airway resistance, and static compliance) are obtained .Blood samples are drawn simultaneously from the arterial catheters for gas analysis. Data were collected after induction of anesthesia (T0) after 1 h (T1), 2 h (T2), 3 h (T3) and at the end of surgery.
Primary outcome: evaluate the fluids effects on oxygenation, respiratory mechanics
Secondary outcome: Incidence of surgery related complications
Università degli Studi di Ferrara is the lead sponsor of 64 studies on the registry; 10 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
group cristalloid (ringer lactate)
Drug: Cristalloid administration
colloid: cristalloid in according to cardiac output
Drug: Group Colloid
Group Colloid: cristalloid 1:2 (gelofusine: ringer lactate)
Only Ringer Lactate administration
effects on oxygenation, respiratory mechanics
Lung compliance (l/cmH20), Airaway resistance (cmH2O/L/sec) and PaO2 will be measured
Time frame: every 30 minutes till the end of surgery
Incidence of respiratory complications
Complications like acute respiratory failure, pneumonia and ARDS will be recorded
Time frame: 28 days
This study is status unknown, as verified in Nov 2016. You cannot join it, but the record below documents what was studied.
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Università degli Studi di Ferrara