An interventional study of Oocyte retrieval will be performed 36 h or 38 h after hCG administration in Subfertility, sponsored by Aristotle University Of Thessaloniki. Completed at 1 site in Greece. Open to female participants aged 20 Years to 43 Years. Per ClinicalTrials.gov, last updated 2014-05-28.
Sponsored by Aristotle University Of Thessaloniki · Not applicable, Interventional, and Treatment
During controlled ovarian hyperstimulation (COH), human chorionic gonadotrophin (hCG) is administered to trigger the final follicular maturation before oocyte retrieval, in an attempt to mimic the physiologic effects of LH. The hCG is administered when more than three follicles ≥17mm in mean diameter have developed.
The time interval between hCG administration and oocyte retrieval is of critical importance since the time after luteinizing stimulus is a period of intense processes including the start of luteinization, expansion of cumulus cells and oocyte meiotic maturation.
The commonly practiced hCG administration time of 33 to 36 h in most IVF cycles aims to avoiding spontaneous ovulation before oocyte retrieval. However, several studies have shown that significantly more high quality embryos have been obtained with a prolonged hCG-to-oocyte interval of 38 h. It has been hypothesized that longer interval would be beneficial in improving oocyte quality and achieving optimal maturation.
Currently there are no data on the effect of the time interval between hCG administration and oocyte retrieval on IVF outcome in GnRH antagonist cycles. The aim of this study is to determine whether there is any difference in in vitro fertilization outcome when oocyte retrieval takes place at 36 h or 38 h following hCG administration
2,541 studies on the registry are indexed under Infertility; 405 are open to participants now.
This study's enrollment of 154 is above the median of 120 across 1,722 interventional studies indexed under Infertility.
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Exclusion Criteria:
Oocyte retrieval will be performed 36 hours after hCG administration
Procedure: Oocyte retrieval will be performed 36 h or 38 h after hCG administration
Oocyte retrieval will be performed 38 hours after hCG administration
Procedure: Oocyte retrieval will be performed 36 h or 38 h after hCG administration
Oocyte retrieval will be performed 36 h or 38 h after hCG administration
Also known as: oocyte retrieval at 36 hours following hCG administration, oocyte retrieval at 38 hours following hCG administration
retrieval rate (cumulus-oocyte complexes/ follicles> 11 mm)
Time frame: up to 38 h after hCG administration
Clinical pregnancy rate (evidence of intrauterine sac with fetal heart activity at 6-8 weeks of gestation)
Time frame: At 6-8 weeks of gestation
Total number of oocytes retrieved
Time frame: up to 38 h after hCG administration
This study is completed, as verified in May 2014. You cannot join it, but the record below documents what was studied.
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