Status unknownNCT02042963KNOW-KTUpdated Jan 23, 2014

KoreaN Cohort Study for Outcome in Patients With Kidney Transplantation (KNOW-KT)

An observational study in Kidney Transplant Recipients and Complications After Kidney Transplant, sponsored by Seoul National University Hospital. Status unknown at 1 site in Korea, Republic of. Per ClinicalTrials.gov, last updated 2014-01-23.

Sponsored by Seoul National University Hospital · Observational

The sponsor has not verified this record recently (last verified Jan 2014), so the status shown — last known as Enrolling by invitation — may be out of date.

Study type: Observational
Model: Cohort
Time perspective: Prospective
Enrollment: 1,000
Sex: All

Study summary

KNOW-KT (KoreaN cohort study for Outcome in patients With KT: A 9-year Longitudinal cohort study of the Korean adult KT patients), funded by Korea Center for Disease Control and Prevention (KCDC) was established in 2012 by a group of transplant physicians, transplant surgeons, nephrologists, epidemiologists, and biostatisticians in Korea.

We aimed to establish an adult KT cohort, to investigate the renal allograft outcomes, mortality, complications, and to explore traditional or nontraditional risk factors for morbidity and mortality. We established a bio-bank to integrate clinical and biological information. Here, we report design and method of the KNOW-KT.

Conditions studied

Kidney Transplant Recipients
Complications After Kidney Transplant

Keywords

The cohort of Asian kidney transplant recipients
The cohort of metabolic complication after kidney transplant
The biorepository of Asian kidney transplant recipients

In context

Lead sponsor

Seoul National University Hospital is the lead sponsor of 1,860 studies on the registry; 275 are open to participants now.

Of its 12 completed or terminated interventional studies of FDA-regulated products, 2 (17%) have results posted.

Counted across the registry records on this site, refreshed daily.

Who can participate

Ages eligible: Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible: All
Accepts healthy volunteers: No
Sampling method: Non-probability sample

Study population

Kidney transplant recipients and their donors (donors for baseline data)

Inclusion criteria

Recipients and Donors of kidney transplant

Exclusion criteria

Exclusion Criteria:

Multi-organ transplant recipients

Study design

Observational model: Cohort
Time perspective: Prospective
Enrollment: 1,000 participants (estimated)
Target follow-up: 9 Years
Patient registry: Yes
Biospecimen retention: Samples with dna

Groups and cohorts

KNOW-KT
1000 Kidney transplant recipients in Korea

What researchers measure

Primary outcomes

overall mortality
Time frame: 9 years
Allograft survival
defined as re-transplant or initiation of maintenance dialysis
Time frame: 9 years

Secondary outcomes

cardiovascular event
Acute Myocardial Infarction Revascularization : PCI or CABG Stroke Admission from Congestive heart failure
Time frame: 9 years
Albuminuria
Time frame: 9 years
Acute Rejection
Time frame: 9 years
New onset of diabetes after transplant
Time frame: 9 years
Quality of Life
Time frame: 2 years

Study locations

1 site

Seoul National Univeristy Hospital
Seoul, Korea, Republic of

References and documents

Publications

Jung HY, Jeon Y, Huh KH, Park JB, Kim MG, Lee S, Han S, Ro H, Yang J, Ahn C, Cho JH, Park SH, Kim YL, Kim CD. Pretransplant and Posttransplant Alcohol Consumption and Outcomes in Kidney Transplantation: A Prospective Multicenter Cohort Study. Transpl Int. 2022 May 30;35:10243. doi: 10.3389/ti.2022.10243. eCollection 2022. PubMed 35707634 ↗
Hong N, Lee J, Kim HW, Jeong JJ, Huh KH, Rhee Y. Machine Learning-Derived Integer-Based Score and Prediction of Tertiary Hyperparathyroidism among Kidney Transplant Recipients: An Integer-Based Score to Predict Tertiary Hyperparathyroidism. Clin J Am Soc Nephrol. 2022 Jul;17(7):1026-1035. doi: 10.2215/CJN.15921221. Epub 2022 Jun 10. PubMed 35688469 ↗
Yang J, Lee J, Huh KH, Park JB, Cho JH, Lee S, Ro H, Han SY, Kim YH, Jeong JC, Park BJ, Han DJ, Park SB, Chung W, Park SK, Kim CD, Kim SJ, Kim YS, Ahn C; KNOW-KT Study Group. KNOW-KT (KoreaN cohort study for outcome in patients with kidney transplantation: a 9-year longitudinal cohort study): study rationale and methodology. BMC Nephrol. 2014 May 9;15:77. doi: 10.1186/1471-2369-15-77. PubMed 24884405 ↗

Updates

Tracking since Sep 25, 2026

No changes since tracking began. The registry record was last updated on Jan 23, 2014, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗

Registry details

Key details

Study ID: NCT02042963
Lead sponsor: Seoul National University Hospital
Collaborators: Asan Medical Center, Chonbuk National University Medical School, Gachon University Gil Medical Center, Keimyung University Dongsan Medical Center, Korea University, Kyungpook National University Hospital, Samsung Medical Center, Medical Research Collaborating Center, Seoul, Korea, Yonsei University, Seoul National University College of Medicine
Responsible party: Curie Ahn (Professor, Seoul National University Hospital) — Principal investigator
First posted: Jan 23, 2014
Start date: Mar 2012
Primary completion: Feb 2021 (estimated)
Last update: Jan 23, 2014

Oversight

Data monitoring committee: Yes

View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Jan 2014. You cannot join it, but the record below documents what was studied.

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