CClinicalTrials.gg
Status unknownNCT02023892Updated May 15, 2014

Single Dose of Atorvastatin and Circulating Endothelial Microparticles

A Phase 4 interventional study of atorvastatin and placebo in Endothelium and Hydroxymethylglutaryl-CoA Reductase Inhibitors, sponsored by Sun Yat-sen University. Status unknown. Open to participants aged 18 Years to 30 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2014-05-15.

Sponsored by Sun Yat-sen University · Phase 4, Interventional, and Prevention

The sponsor has not verified this record recently (last verified May 2014), so the status shown — last known as Not yet recruiting — may be out of date.
Phase
Phase 4
Study type
Interventional
Enrollment
30
Allocation
Randomized
Ages
18 Years to 30 Years
Sex
All
01

Study summary

Healthy subjects take single dose of 80mg atorvastatin, then measured their circulating endothelial microparticles and flow-mediated vasodilation in the brachial artery by ultrasound at different time points.

02

Conditions studied

  • Endothelium
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
03

In context

Lead sponsor

Sun Yat-sen University is the lead sponsor of 1,644 studies on the registry; 602 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 30 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • healthy youth

Exclusion criteria

Exclusion Criteria:

  • acute pathologies
  • familial history of cardiovascular disease
  • smoking or drinking alcohol
05

Study design

Phase
Phase 4
Primary purpose
Prevention
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Quadruple (Participant, Care provider, Investigator, Outcomes assessor)
Enrollment
30 participants (estimated)

Study arms

  • Experimental
    atorvastatin

    atorvastatin 20mg tablet, single dose of 80mg by mouth

    Drug: atorvastatin

  • Placebo comparator
    placebo

    placebo 20mg tablet, single dose of 80mg by mouth

    Drug: placebo

Interventions

  • Drugatorvastatin

    Also known as: Liptor

  • Drugplacebo

    Also known as: sugar pill manufactured to mimic atorvastatin 20mg tablet

06

What researchers measure

Primary outcomes

  1. change of circulating endothelial microparticles

    Time frame: from 1h to 24h after taking atorvastatin

07

Study locations

No study locations are listed for this record.

08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 15, 2014, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT02023892
Lead sponsor
Sun Yat-sen University
Responsible party
Yi-jun Huang, PhD (Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University) — Principal investigator
First posted
Dec 30, 2013
Start date
Jun 2014
Primary completion
Aug 2014 (estimated)
Last update
May 15, 2014

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in May 2014. You cannot join it, but the record below documents what was studied.

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