A Study Exmining the Effect of Multiple Doses of Bitopertin on the Single Dose Pharmacokinetics of Midazolam in Healthy Volunteers.

• Healthy male and female volunteers, 18 to 65 years of age, inclusive.
• A BMI between 18 to 30 kg/m2, inclusive.
• Healthy as determined by the Investigator on the basis of medical/surgical history, physical examination, clinical laboratory test results, vital signs and 12-lead electrocardiogram (ECG)
• Female participants must use effective contraception as defined by the protocol and cannot be pregnant or breastfeeding
• Non-smoker or smoker of fewer than 10 cigarettes per day
• Must be able to refrain from smoking during the in-patient stay

Exclusion Criteria:

• Personal or family history of congenital long QT syndrome or family history of sudden death
• Any major illness within the 4 weeks prior to dosing or any acute disease state within 7 days prior to study start
• History of alcoholism, drug abuse or addiction within the last year prior to study start, or suspicion of drug abuse/addiction or alcohol use prior to study start
• Current alcohol consumption averaging more than 24 g of alcohol per day
• Any significant allergic reactions against any drug, or multiple allergies in the judgment of the Investigator