A Phase 4 interventional study of CMR in Type 2 Diabetes, sponsored by Xiang Guang-da. Completed at 1 site in China. Open to male participants aged 30 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2014-04-07.
Sponsored by Xiang Guang-da · Phase 4, Interventional, and Health services research
Magnetic resonance (MR) imaging is a widely used and well-established noninvasive medical diagnostic imaging tool. By using a static and a gradient magnetic field in combination with a radiofrequency field (RF), MR provides excellent contrast among different tissues of the body. Although long-term effects on human health from exposure to strong static magnetic fields seem unlikely, acute effects such as vertigo, nausea, change in blood pressure, reversible arrhythmia, and neurobehavioural effects have been documented from occupational exposition to 1.5 T. Cardiac MR (CMR) imaging requires some of the strongest and fastest switching electromagnetic gradients available in MR exposing the patients to the highest administered energy levels accepted by the controlling authorities. Studies focusing on experimental teratogenic or carcinogenic effects of MR revealed conflicting results. Since CMR is emerging as one of the fastest growing new fields of broad MR application, it is of particular concern that a recent in vitro study with CMR sequences has reported on CMR-induced DNA damages in white blood cells up to 24 h after exposure to 1.5 T CMR. Therefore, we hypothesized that CMR can induce the damage of endothelium and endothelial progenitor cells in type 2 diabetes
10,925 studies on the registry are indexed under Diabetes Mellitus; 1,319 are open to participants now.
This study's enrollment of 88 is close to the median of 80 across 8,367 interventional studies indexed under Diabetes Mellitus.
Browse Diabetes Mellitus studies →Xiang Guang-da is the lead sponsor of 11 studies on the registry; none are open to participants now.
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Endothelial function, oxidative stress and inflammation were measured before and after CMR.
Device: CMR
The subjects keep supine position the MR machine as same time as experimental group when the MR machine is power off. The endothelial function, oxidative stress and inflammation were measured before and after this procedure". This group is called the non-CMR group or sham CMR group.
Device: CMR
Healthy subjects (30) will be enrolled as controls at baseline.
Changes of endothelium-dependent arterial dilation before and after CMR in type 2 diabetes
The endothelium-dependent arterial dilation was measured at baseline, 1day, 2 day, 3 day after CMR.
Time frame: 3 days
Changes of endothelial progenitor cells before and after CMR in peripheral blood
The numbers of endothelial progenitor cells was determined at baseline, 1 day, 2 day, 3 day after CMR.
Time frame: 3 days
This study is completed, as verified in Apr 2014. You cannot join it, but the record below documents what was studied.
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Xiang Guang-da