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CompletedNCT01971424MagnesiumUpdated Oct 29, 2013

Assessment of Physical Performance After Oral Supplementation of Magnesium in a Sample of Old Women in Good Health

An interventional study of Mg oxide and healthy diet in Age Related Muscle Loss, sponsored by University of Padova. Completed at 1 site in Italy. Open to female participants aged 65 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2013-10-29.

Sponsored by University of Padova · Not applicable, Interventional, and Basic science

Phase
Not applicable
Study type
Interventional
Enrollment
100
Allocation
Randomized
Ages
65 Years and older
Sex
Female
01

Study summary

Magnesium deficiency is associated also in the elderly with low physical performance; nevertheless trials about the effect of supplementation of magnesium on physical performance are not available in old people. The aim of our study is to investigate whether 12-weeks of oral magnesium supplementation improves physical performance in healthy elderly women

02

Conditions studied

  • Age Related Muscle Loss

Keywords

  • magnesium
  • SPPB
  • strength
  • physical performance
  • 24 hour magnesuria
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In context

Lead sponsor

University of Padova is the lead sponsor of 210 studies on the registry; 42 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
65 Years and older
Sexes eligible
Female
Accepts healthy volunteers
Yes

Inclusion criteria

  • People over 65 years, not residents in nursing home, in good health

Exclusion criteria

Exclusion Criteria:

  • previous supplementation of calcium, potassium or magnesium
  • use of pump proton inhibitors or digitalis
  • important co-mordidities such renal failure
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Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
100 participants (actual)

Study arms

  • Experimental
    Mg oxide

    Participants were supplemented for 12-weeks with 300 mg of daily oral magnesium oxide.

    Dietary Supplement: Mg oxide · Other: healthy diet

  • No intervention
    Controls

    The control group was educated by a trained dietician to follow a healthy diet.

Interventions

  • Dietary supplementMg oxide

    Also known as: Magnesium oxide

  • Otherhealthy diet
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What researchers measure

Primary outcomes

  1. Changes in short physical performance battery (SPPB)

    Time frame: Baseline and after 12 weeks

Secondary outcomes

  1. Changes in appendicular skeletal mass (ASMMI)

    Time frame: Baseline and after 12 weeks

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Study locations

1 site
  • Geriatrics Division, Department of Medicine
    Padova, 35128, Italy
08

References and documents

Publications

  • Dominguez LJ, Barbagallo M, Lauretani F, Bandinelli S, Bos A, Corsi AM, Simonsick EM, Ferrucci L. Magnesium and muscle performance in older persons: the InCHIANTI study. Am J Clin Nutr. 2006 Aug;84(2):419-26. doi: 10.1093/ajcn/84.1.419. PubMed 16895893 ↗
  • Veronese N, Berton L, Carraro S, Bolzetta F, De Rui M, Perissinotto E, Toffanello ED, Bano G, Pizzato S, Miotto F, Coin A, Manzato E, Sergi G. Effect of oral magnesium supplementation on physical performance in healthy elderly women involved in a weekly exercise program: a randomized controlled trial. Am J Clin Nutr. 2014 Sep;100(3):974-81. doi: 10.3945/ajcn.113.080168. Epub 2014 Jul 9. PubMed 25008857 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 29, 2013, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT01971424
Lead sponsor
University of Padova
Responsible party
Giuseppe Sergi (Medical Doctor, University of Padova) — Principal investigator
First posted
Oct 29, 2013
Start date
Jan 2012
Primary completion
Mar 2013
Completion
Mar 2013
Last update
Oct 29, 2013

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Oct 2013. You cannot join it, but the record below documents what was studied.

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