A Phase 2/3 interventional study of Propranolol and Placebo in Burn, sponsored by The University of Texas Medical Branch, Galveston. Terminated at 4 sites in United States. Open to participants aged Up to 18 Years. Per ClinicalTrials.gov, last updated 2019-09-24.
Sponsored by The University of Texas Medical Branch, Galveston · Phase 2/3, Interventional, and Treatment
To determine the safety and efficacy of administration of propranolol for reducing heart rate and blood pressure in burn injury.
Other purposes of this study are to study the effect on muscle function, the infectious process, sepsis, systemic inflammation and long-term scarring. Quality of life will also be looked at over time.
The University of Texas Medical Branch, Galveston is the lead sponsor of 251 studies on the registry; 38 are open to participants now.
Of its 30 completed or terminated interventional studies of FDA-regulated products, 25 (83%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Propranolol by mouth given daily throughout hospitalization for up to 12 months
Drug: Propranolol
Placebo by mouth given daily throughout hospitalization for up to 12 months
Drug: Placebo
Propranolol by mouth given daily throughout hospitalization for up to 12 months
Also known as: Metoprolol, inderal
Placebo by mouth given daily throughout hospitalization for up to 12 months.
Also known as: Control
Resting heart rate multiplied by the systolic blood pressure measurement= rate pressure product
Multiply the subjects resting heart rate and systolic blood pressure measurements and average every 24 hours while hospitalized (an average of 4 weeks)
Time frame: Measured during acute hospital stay, an average of 4 weeks.
Number of deaths
Number of deaths will be compared between placebo group and propranolol treatment groups.
Time frame: time of randomization up to one year
Plan to share: No
No publications or documents are linked to this record.
This study is terminated, as verified in Aug 2018. You cannot join it, but the record below documents what was studied.
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The University of Texas Medical Branch, Galveston