An interventional study of electroencephalography and Blood sampling in Hyperalimentation and Obesity, sponsored by Hospices Civils de Lyon. Completed at 1 site in France. Open to female participants aged 20 Years to 55 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-12-19.
Sponsored by Hospices Civils de Lyon · Not applicable, Interventional, and Basic science
The P300 is one of the cognitive wave of the Event-Related Potential (ERP) that is used to investigate the cognitive process. The P300 component are accepted as electro-physiological markers of neuropsychiatric disorders like alcoholism or drug addiction.
Recent scientific data suggest that eating disorders, leading to weight gain and obesity, will be similar of those of drug addiction: it is the incentive sensitization theory that implicates the dopaminergic reward system.
The aim of this cross-sectional study is to investigate the alteration of P300 auditory ERP in obese women with eating disorders in comparison with obese and lean women without eating disorders.
Exclusion Criteria:
Obese women with eating disorders : women with BMI higher or equal 35 and disinhibition score to TFEQ strictly higher to 8
Procedure: electroencephalography · Biological: Blood sampling · Behavioral: Questionnaires regarding eating habits (TFEQ, EDI) and anxiety/depression (HAD)
Obese women without eating disorders : women with BMI higher or equal to 35 and disinhibition score to TFEQ lower or equal to 8
Procedure: electroencephalography · Biological: Blood sampling · Behavioral: Questionnaires regarding eating habits (TFEQ, EDI) and anxiety/depression (HAD)
Lean women : women with BMI from 18.5 to 24.5 and disinhibition score to Three-Factor Eating Questionnaire (TFEQ)lower or equal to 8
Procedure: electroencephalography · Biological: Blood sampling · Behavioral: Questionnaires regarding eating habits (TFEQ, EDI) and anxiety/depression (HAD)
P300 amplitude
The auditory event-related potentials measure will be elicited with an auditory oddball paradigm. The activity will be recorded thanks to electroencephalography from frontal, central and parietal electrodes, using an electrode cap.
Time frame: At the beginning of the exploration visit (when patient is fasting) that will take place between 1 and 15 days after inclusion
Auditory ERP ( latency P300, amplitude and latency of N2 wave recorded from frontal, central and parietal electrode)
The technique of auditory ERP will be an auditory discriminated task paradigm
Time frame: fasting (up to 15 days)
assessment of dietary restraints and disinhibition
Participants will complete self-report questionnaires including Three-Factor Eating Questionnaire and Eating Disorders Inventory. The lean subjects should not have TFEQ disinhibition score more than 8. The obese subjects will be separated on two groups depending on TFEQ dishinibition score (strictly greater than 8, the obese with eating disorder, less than or equal 8, obese without eating disorder).
Time frame: fasting (up to 15 days)
glucose, insulin, leptin and ghrelin plasmatic rate
respectively reverse-phase high-performance liquid chromatography (RP-HPLC), ImmunoRadio Metric (IRMA) and ELISA assay
Time frame: fasting (up to 15 days)
dopamine D2 receptor Taq 1 polymorphism
Real time PCR
Time frame: fasting (up to 15 days)
Dietary intake and eating patterns
Women will be interviewed by dietician, using a 24 h food questionnaire with additional questions regarding health and eating habits
Time frame: At day 1 and at day 15
This study is completed, as verified in Dec 2025. You cannot join it, but the record below documents what was studied.
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Hospices Civils de Lyon