An interventional study of randomization between the two GnRH analogues (agonist and antagonist) in Infertility and In Vitro Fertilization Protocols, sponsored by Hospital de Clinicas de Porto Alegre. Status unknown at 2 sites in Brazil. Open to female participants aged 20 Years to 39 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2013-11-07.
Sponsored by Hospital de Clinicas de Porto Alegre · Not applicable, Interventional, and Basic science
This study is intended to evaluate ovarian cells after being submitted do different in vitro fertilization protocols. The investigators will analyze hormones secretion and intracellular mechanisms of these cells comparing the GnRH agonist protocol and the GnRH antagonist protocol.
2,506 studies on the registry are indexed under Infertility; 407 are open to participants now.
This study's planned enrollment of 28 is below the median of 120 across 1,698 interventional studies indexed under Infertility.
Browse Infertility studies →Hospital de Clinicas de Porto Alegre is the lead sponsor of 450 studies on the registry; 61 are open to participants now.
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Exclusion Criteria:
GnRH long agonist protocol of invitro fertilization
Drug: randomization between the two GnRH analogues (agonist and antagonist)
GnRH fixed antagonist protocol of in vitro fertilization
Drug: randomization between the two GnRH analogues (agonist and antagonist)
Evaluation of steroid secretion and enzyme expression in in vitro luteinized granulosa cells
evaluation of granulosa cells hormone secretion and enzyme expression in media culture 48 hours after ovarian punction
Time frame: after 48h in media culture
Number of retrieved oocytes
Immediately after the ovarian punction the number of retrieved oocytes will be evaluated
Time frame: After the ovarian punction
number of embryos
the embryologist will verify the number of embryos after 3 to 5 days from the ovarian punction
Time frame: 3 to 5 days after ovarian punction
Subgroup analyses comparing FSH versus HMG protocols
It will be verified the differences between the two types of gonadotrophins in ovarian stimulation regarding: units of gonadotrophins used, number of retrieved oocytes,number of embryos and embryo score
Time frame: after ovarian punction
This study is status unknown, as verified in Nov 2013. You cannot join it, but the record below documents what was studied.
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Hospital de Clinicas de Porto Alegre