An observational study in Exercise Induced Asthma, sponsored by Universitaire Ziekenhuizen KU Leuven. Completed at 1 site in Belgium. Open to participants aged 14 Years to 25 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-07-16.
Sponsored by Universitaire Ziekenhuizen KU Leuven · Observational
High school elite training programs are today more and more under development in several 'elite sport schools' in Belgium, in order to select and train future elite athletes already at young age. Little is known about the effects of sustained training on the potential development of asthma in adolescents during lung growth. It would be of great importance to be able to select the individuals at risk to develop exercise-induced asthma, already at the start of their enrollment in the 'elite sport school. This would allow physicians to follow their lung function parameters very closely and regularly; and, if necessary, start treatment early after the first signs of exercise-induced asthma.
Competitive swimmers, competitive indoor athletes and control individuals performing sports at a recreational level will be recruited for the study.
They will perform a sport-specific training (swimmers and controls: swimming for 90 minutes, indoor athletes: basketball or volleyball for 90 minutes)
Baseline measurements:
Measurements immediately after training:
Measurements 24 hours after training:
52 studies on the registry are indexed under Asthma, Exercise-Induced; 3 are open to participants now.
Browse Asthma, Exercise-Induced studies →Universitaire Ziekenhuizen KU Leuven is the lead sponsor of 963 studies on the registry; 267 are open to participants now.
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Competitive swimmers, competitive indoor athletes and healthy individuals
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Exclusion Criteria:
Swimmers performing at national or international level
Indoor athletes performing at national or international level
Individuals performing sports at a recreational level
Measurement of airway inflammation
Airway inflammation upper and lower airways will be assessed by collection of nasal fluid (nasal sponge will be inserted in nostril for 5 minutes), Fraction of exhaled Nitric Oxide measurement and sputum induction.
Time frame: Baseline, immediately after and 24 hours after sport-specific training
Measurement of exercise induced bronchoconstriction
Exercise induced bronchoconstriction will be assessed by eucapnic voluntary hyperventilation test.
Time frame: baseline
Detection of allergy
-Allergy will be assessed by skin prick test (on skin) and immunocap test (in blood, 1 tube of 10 ml).
Time frame: baseline
Assessment of upper and lower airway symptoms
-Upper and lower airway symptoms will be assessed by questionnaires (SinoNasal Outcome Measure-22, Visual Analogue Score, Asthma Symptom Score and Juniper Score)
Time frame: Baseline, immediately after and 24 hours after sport-specific training
Measurement of lung function and nasal patency
-Lung function and nasal patency will be measured by spirometry and Peak Nasal Inspiratory Flow measurement.
Time frame: at baseline, immediately after and 24 hours sport-specific training
Plan to share: Yes — Overall results are presented in a closed session for participants and parents. Confidential individual data are afterwards discussed with the respective parents and participants.
This study is completed, as verified in Jul 2018. You cannot join it, but the record below documents what was studied.
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