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CompletedNCT01917786Updated Jan 8, 2016

Effect of Dexmedetomidine on QT Interval in Pediatric Patients Under General Anesthesia

An observational study in Surgery, sponsored by Senthil G. Krishna. Completed at 1 site in United States. Per ClinicalTrials.gov, last updated 2016-01-08.

Sponsored by Senthil G. Krishna · Observational

Study type
Observational
Model
Case-control
Time perspective
Prospective
Enrollment
50
Sex
All
01

Study summary

Various medications used in anesthesia have been implicated in the prolongation of QT interval. Recently, there has been an increase in the use of dexmedetomidine in patients presenting for surgeries given its beneficial sedative, anxiolytic, and analgesic properties. It has several desirable properties including minimal respiratory side effects as well as the ability to decrease intraoperative and postoperative analgesic requirements. In many of the patients who present for routine surgical procedures, dexmedetomidine is a common component of their anesthetic care. This is a study to assess the effects of dexmedetomidine on the QT interval in children presenting for surgery.

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Conditions studied

  • Surgery
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In context

Lead sponsor

Senthil G. Krishna is the lead sponsor of 5 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients receiving dexmedetomidine as part of their surgical anesthesia.

Inclusion criteria

  • ASA grade 1 or 2.
  • Scheduled to receive dexmedetomidine.

Exclusion criteria

Exclusion Criteria:

  • Known allergy to dexmedetomidine.
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Study design

Observational model
Case-control
Time perspective
Prospective
Enrollment
50 participants (actual)
Patient registry
No

Groups and cohorts

  • Dexmedetomidine patients

    Surgical patients receiving dexmedetomidine.

    Device: ECG

  • Control patients

    Surgical patients not receiving dexmedetomidine.

    Device: ECG

Interventions

  • DeviceECG
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What researchers measure

Primary outcomes

  1. Change in QT interval

    ECG will be done to assess QT interval prior to induction (baseline), after induction (5 mins.) and after dexmedetomidine (10 mins.)

    Time frame: Baseline, 5 mins., 10 mins.

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Study locations

1 site
  • Nationwide Children's Hospital
    Columbus, Ohio 43205, United States
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References and documents

Publications

  • Kako H, Krishna SG, Sebastian R, Smith K, Tobias JD. Effect of dexmedetomidine on the QT interval in pediatric patients undergoing general anesthesia. J Anesth. 2015 Dec;29(6):862-7. doi: 10.1007/s00540-015-2056-2. Epub 2015 Aug 4. PubMed 26238761 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 8, 2016, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT01917786
Lead sponsor
Senthil G. Krishna
Responsible party
Senthil G. Krishna (Assistant Clinical Professor, Nationwide Children's Hospital) — Sponsor-investigator
First posted
Aug 7, 2013
Start date
Jul 2013
Primary completion
Feb 2015
Completion
Feb 2015
Last update
Jan 8, 2016

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jan 2016. You cannot join it, but the record below documents what was studied.

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