CClinicalTrials.gg
CompletedNCT01893268Updated May 14, 2018

An Observational Study of Avastin (Bevacizumab) in Elderly Patients With Non-Squamous Non-Small Cell Lung Cancer in Clinical Practice

An observational study in Non-Squamous Non-Small Cell Lung Cancer, sponsored by Hoffmann-La Roche. Completed at 88 sites in France. Open to participants aged 65 Years and older. Per ClinicalTrials.gov, last updated 2018-05-14.

Sponsored by Hoffmann-La Roche · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
279
Ages
65 Years and older
Sex
All
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Study summary

This prospective, observational study will assess the effectiveness and safety of Avastin (bevacizumab) as 1st line therapy in elderly patients with advanced non-squamous non-small cell lung cancer in clinical practice. Therapy with Avastin and standard chemotherapy will be administered according to the treating physician. Data will be collected for approximately 4 years.

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Conditions studied

  • Non-Squamous Non-Small Cell Lung Cancer
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In context

Lung Neoplasms

7,243 studies on the registry are indexed under Lung Neoplasms; 1,557 are open to participants now.

This study's enrollment of 279 is above the median of 189 across 1,514 observational studies indexed under Lung Neoplasms.

Browse Lung Neoplasms studies →

Lead sponsor

Hoffmann-La Roche is the lead sponsor of 2,061 studies on the registry; 85 are open to participants now.

Of its 319 completed or terminated interventional studies of FDA-regulated products, 239 (75%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
65 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

Patients aged over 65 years with non-squamous non-small cell lung cancer

Inclusion criteria

  • Adult patients, >= 65 years of age
  • Diagnosis of advanced non squamous Non-Small Cell Lung Carcinoma (nsNSCLC, stage IIIB or IV) for whom the physician has decided to initiate a treatment with Avastin combined with chemotherapy as 1st line therapy
  • Having received oral and written information about the study, and having signed a written consent form

Exclusion criteria

Exclusion Criteria:

  • Participation in a cancer clinical trial with an investigational medicinal product other than this study
  • Patient previously treated with Avastin
  • Patient under supervision or guardianship
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
279 participants (actual)

Groups and cohorts

  • Cohort
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What researchers measure

Primary outcomes

  1. Proportion of patients treated with a chemotherapy in combination with Avastin including description of chemotherapy regimens and management of Avastin treatment

    Time frame: Approximately 4 years

Secondary outcomes

  1. Characteristics of patients with advanced non-squamous non-small cell lung cancer

    Time frame: Approximately 4 years

  2. Tumor characteristics of patients with advanced non-squamous non-small cell lung cancer

    Time frame: Approximately 4 years

  3. Progression-free survival

    Time frame: Approximately 4 years

  4. Overall survival

    Time frame: Approximately 4 years

  5. Quality of Life

    Time frame: Approximately 4 years

  6. Safety: Incidence of adverse events

    Time frame: Approximately 4 years

  7. Reasons of non-use of Avastin as first-line therapy

    Time frame: Approximately 4 years

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Study locations

88 sites
  • Clinique Du Docteur Calabet; Cromg
    Agen, 47000, France
  • Ch Du Pays D Aix; Pneumologie
    Aix En Provence, 13616, France
  • Poly Parc Rambot La Provencale; Chimiotherapie Ambulatoire
    Aix En Provence, 13617, France
  • Cabinet Medical
    Amiens, 80090, France
  • Centre Hospitalier Uni Ire; Pneumology
    Angers, 49933, France
  • Chic Cote Basque Bayonne; Pneumologie
    Bayonne, 64109, France
  • HOPITAL JEAN MINJOZ; Oncologie
    Besancon, 25030, France
  • CH Germon ET Gauthier; Pneumologie
    Beuvry, 62660, France
  • Ch De Beziers; Pneumologie
    Beziers, 34525, France
  • Hopital Avicenne; Cancerologie
    Bobigny, 93009, France
  • Polyclinique Bordeaux Nord Aquitaine; Chimiotherapie Radiotherapie
    Bordeaux, 33077, France
  • Centre Hospitalier Fleyriat; Oncologie/Hematologie
    Bourg En Bresse, 01012, France
  • Ch De Fleyriat; Pneumologie 1
    Bourg En Bresse, 01012, France
  • Hia Clermont Tonnerre; Pneumologie
    Brest, 29240, France
  • Ch De Brive La Gaillarde; Radiotherapie Oncologie
    Brive La Gaillarde, 19312, France
  • Hopital Louis Pradel; Pneumologie
    Bron, 69677, France
  • Hopital Pierre Nouveau; Pneumologie
    Cannes, 06401, France
  • Ch Antoine Gayraud; Oncologie
    Carcassonne, 11890, France
  • Clinique Du Parc; Hematologie
    Castelnau Lez, 34170, France
  • Ctre Medical Nicolas de Pontoux
    Chalon Sur Saone, 71100, France
  • Ch De Chauny; Pneumologie
    Chauny, 02303, France
  • CH Du Cotentin Site De Cherbourg; Hopital De Jour
    Cherbourg Octeville, 50102, France
  • Hopital Gabriel Montpied; Service de Pneumologie
    Clermont-ferrand, 63003, France
  • Centre Jean Perrin; Hopital De Semaine
    Clermont-Ferrand, 63011, France
  • Hopital Louis Pasteur; Pneumologie Tabacologie
    Colmar, 68024, France
  • Centre Hospitalier Alpes Leman CHAL;Pneumologie
    Contamine Sur Arve, 74130, France
  • Clinique Des Cedres; Pneumologie
    Cornebarrieu, 31700, France
  • Centre Hospitalier Intercommunal; Service de Pneumologie
    Creteil, 94010, France
  • Chu Site Du Bocage;Pneumologie
    Dijon, 21079, France
  • Ch De La Dracenie; Pneumologie
    Draguignan, 83007, France
  • Centre D Oncologie Dunkerquois
    Dunkerque, 59240, France
  • Chi Emile Durkheim Site Epinal; Pneumologie
    Epinal, 88021, France
  • Chi Alpes Du Sud Site De Gap; Pneumologie
    GAP, 05007, France
  • Hopital Nord Ouest;Unite 2c
    Gleize, 69400, France
  • CH Emmanuel Rain; Oncologie
    Gonesse, 95503, France
  • Hopital Prive De Chantilly; Medecine
    Gouvieux Chantilly, 60500, France
  • Hopital D Hayange;Medecine A Et P
    Hyeres, 83400, France
  • Centre Oscar Lambret; Chir Cancerologie General
    Lille, 59000, France
  • Hopital Saint Vincent; Consult et Explorations
    Lille, 59020, France
  • Hopital Calmette; Pneumologie Oncologie Ouest
    Lille, 59037, France
  • Clinique Chenieux; Oncology
    Limoges, 87039, France
  • Hopital Du Cluzeau; Service de Pathologie Respiratoire
    Limoges, 87042, France
  • Hopital Dupuytren; Pneumologie
    Limoges, 87042, France
  • Centre Hospitalier Général; Pneumologie
    Longjumeau, 91161, France
  • Ch Bretagne Sud Site Scorff; Oncologie Medicale
    Lorient, 56100, France
  • Centre Medical Parot
    Lyon, 69006, France
  • Centre Hospitalier François Quesnay; Pneumologie-Neurologie
    Mantes La Jolie, 78200, France
  • Hôpital Saint Joseph; Oncologie Medicale
    Marseille, 13285, France
  • Centre Hospitalier; Pneumologie
    Metz Tessy, 74370, France
  • Hopital Layne; Medecine Ambulatoire
    Mont-de-marsan, 40024, France
  • Ch De Montauban; Pneumologie
    Montauban, 82013, France
  • Hopital Emile Muller;Pneumologie
    Mulhouse, 68070, France
  • Cabinet Medical
    Nancy, 54000, France
  • Polyclinique Gentilly; CHIMIOTHERAPIE AMBULATOIRE
    Nancy, 54100, France
  • Hopital Caremeau; Pneumologie
    Nimes, 30029, France
  • Clinique sainte marie; chimiotherapie ambulatoire
    Osny, 95520, France
  • Hopital Cochin; Unite Fonctionnelle D Oncologie
    Paris, 75014, France
  • Hopital Saint Louis; Oncologie Medicale
    Paris, 75475, France
  • Hopital Europeen Georges Pompidou; Service D'Oncologie Medicale
    Paris, 75908, France
  • Centre Catalan D' Oncologie
    Perpignan, 66000, France
  • Centre Hospitalier Lyon Sud; Pneumologie
    Pierre Benite, 69495, France
  • CH Rene Dubos; Oncologie
    Pontoise, 95300, France
  • Hopital Laennec; Service de Pneumologie
    Quimper, 29000, France
  • Ch De Rambouillet; Pneumologie Cardiologie
    Rambouillet, 78514, France
  • Cabinet
    Reims, 51100, France
  • Hopital de Pontchaillou; Service de Pneumologie
    Rennes, 35033, France
  • Clinique Saint Hilaire; Sce Chimiotherapie
    Rouen, 76044, France
  • Centre Cardiologique Du Nord; Pneumologie
    Saint Denis, 93200, France
  • Clinique de L'Union; Oncologie
    Saint Jean, 31240, France
  • Cabinet Medical
    Saint Laurent Du Var, 06700, France
  • Hopital Nord; Service de Pneumologie
    Saint Priest En Jarez, 42770, France
  • Ch De Saintonge; Unite 2 Pneumologie
    Saintes, 17108, France
  • Ch De Saint Quentin; Medecine B14
    St Quentin, 02321, France
  • Centre Medical National Mgen; Pneumologie
    Ste Feyre, 23000, France
  • Centre Paul Strauss; Oncologie Medicale
    Strasbourg, 67065, France
  • Hopital Bel Air; Pneumologie Allergologie
    Thionville, 57126, France
  • Hopitaux Du Leman Site Thonon; Pneumologie
    Thonon-les-bains, 74203, France
  • Hia Sainte Anne; Pneumologie
    Toulon, 83041, France
  • Hopital Sainte Musse; Pneumologie
    Toulon, 83056, France
  • Clinique Pasteur; Pneumologie
    Toulouse, 31076, France
  • Groupe Oncorad Garonne; Unite Onco Hematologie
    Toulouse, 31300, France
  • Cabinet Medical
    Tours, 37000, France
  • Hopital Des Hauts Clos; Pneumologie
    Troyes, 10003, France
  • Ch De Valence; Medecine 7
    Valence, 26953, France
  • Centre Alexis Vautrin; Oncologie Medicale
    Vandoeuvre Les Nancy, 54511, France
  • Hopital Robert Schuman; Pneumologie
    Vantoux, 57070, France
  • Gh Mutualiste Les Portes Du Sud; Pneumologie
    Venissieux, 69200, France
  • Hopital Saint Nicolas; Pneumologie
    Verdun, 55107, France
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 14, 2018, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT01893268
Lead sponsor
Hoffmann-La Roche
Responsible party
Sponsor
First posted
Jul 8, 2013
Start date
Jul 25, 2013
Primary completion
Mar 20, 2018
Completion
Mar 20, 2018
Last update
May 14, 2018

Study contacts

Clinical Trials
study director · Hoffmann-La Roche
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in May 2018. You cannot join it, but the record below documents what was studied.

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