An interventional study of transcranial direct current stimulation and sham stimulation in Healthy Older Adults, sponsored by Charite University, Berlin, Germany. Withdrawn at 1 site in Germany. Open to participants aged 50 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2021-05-14.
Sponsored by Charite University, Berlin, Germany · Not applicable, Interventional, and Treatment
The aim of this study is to investigate whether the anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) in healthy older adults leads to an increase in cortical plasticity (change in motor evoked potentials (MEP) in mV).
Charite University, Berlin, Germany is the lead sponsor of 836 studies on the registry; 129 are open to participants now.
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Device: transcranial direct current stimulation
Device: sham stimulation
anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) in healthy older adults
to investigate whether the anodal transcranial direct current stimulation over the primary motor cortex (M1) in healthy older adults increases cortical plasticity (measured via motor evoked potentials)compared to sham stimulation
Time frame: 1 week
Comparison of tDCS-induced changes on central cholinergic activity
to investigate weather anodal transcranial direct-current stimulation affect central cholinergic activity (measured via a TMS-protocol) in healthy older adults compared to sham stimulation
Time frame: 1 week
Comparison of tDCS-induced changes in the learning success
tDCS-induced changes on learning success (performance in a motor learning paradigm in healthy older adults after tDCS vs. sham)
Time frame: 1 week
MR elastography
Comparison of viscoelastic parameters in cerebral MR elastography in healthy older adults
Time frame: 1 week
genetic polymorphism, ApoE4
optional assessment of genetic Apo4 epsilon status for assessment of differences in cortical plasticity and elasticity between Apo4 epsilon positive and negative participants
Time frame: once
This study is withdrawn, as verified in May 2021. You cannot join it, but the record below documents what was studied.
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Charite University, Berlin, Germany