An interventional study of 25g of glucose in 200ml tap water, given orally (plus 50 mg 13C-sodium acetate) and 10g Glucose in 200ml tap water given orally (plus 50 mg 13C-sodium acetate) in Obesity, sponsored by University Hospital, Basel, Switzerland. Completed at 1 site in Switzerland. Open to female participants aged 18 Years to 45 Years. Per ClinicalTrials.gov, last updated 2013-05-10.
Sponsored by University Hospital, Basel, Switzerland · Not applicable, Interventional, and Prevention
The objective of this study is to examine gastric emptying and satiety hormones after oral glucose stimulation in 2 different concentrations in morbidly obese patients after Roux-en-Y-gastric-Bypass.
After gastric bypass many patients suffer from early and/or late dumping syndrome as a reaction to carbohydrate rich meals. Gastric emptying after bypass is accelerated and nutrition enters the intestine faster, which leads to osmotically driven fluid shifts from the blood to the lumen. Late dumping occurs 1-3 h after eating, and is caused by hyperinsulinemia and is therefore characterized by symptoms of hypoglycemia like weakness, sweating, and dizziness. Many people have both types. In most studies examining satiety hormones after oral glucose stimulation in non-operated patients, glucose loads of 50-75g are used. For a measurable GLP-1 rise a threshold of 2 kcal/min. at the intestine is needed. After gastric bypass gastric emptying is accelerated and less glucose is necessary to reach this threshold. The "threshold load" and "tolerable load without dumping symptoms" is not yet know.
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Exclusion Criteria:
25g of glucose in 200ml tap water, given orally (plus 50 mg 13C-sodium acetate)
Dietary Supplement: 25g of glucose in 200ml tap water, given orally (plus 50 mg 13C-sodium acetate)
10g Glucose in 200ml tap water given orally (plus 50 mg 13C-sodium acetate)
Dietary Supplement: 10g Glucose in 200ml tap water given orally (plus 50 mg 13C-sodium acetate)
amount of oral glucose leading to increase in satiety hormones
Time frame: 240 min.
Amount of oral glucose leading to clinical signs of dumping
Time frame: 240min.
Gastric emptying after gastric bypass
Gastric emptying is measured by means of breath test (use of 50 mg 13C-sodium acetate)
Time frame: 240min
This study is completed, as verified in May 2013. You cannot join it, but the record below documents what was studied.
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University Hospital, Basel, Switzerland