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CompletedNCT01821742ECHOKIDSUpdated Jul 8, 2019

Echocardiography in Kids Intensive Care Decision Support

An observational study in Fluid Responsiveness and Cardiac Output, sponsored by Imperial College London. Completed at 1 site in United Kingdom. Open to participants aged Up to 16 Years. Per ClinicalTrials.gov, last updated 2019-07-08.

Sponsored by Imperial College London · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
25
Ages
Up to 16 Years
Sex
All
01

Study summary

A study to determine if echocardiographically derived parameters, plethysmographic variability index and pulse pressure variation predict fluid responsiveness in children on PICU.

Read the detailed description

A study to determine if echocardiographically derived parameters, plethysmographic variability index and pulse pressure variation predict fluid responsiveness in children on PICU. These parameters will be measured pre and post fluid bolus in children prescribed fluid bolus therapy for clinical indications on the PICU. Children will be classified as responders (>10% increase in cardiac output) and non responders (\<10% increase). Appropriate statistical tests will be performed to determine the most useful predictor of an increase in cardiac output following a fluid bolus.

02

Conditions studied

  • Fluid Responsiveness
  • Cardiac Output

Keywords

  • Shock
  • Fluid bolus
  • Cardiac output
  • Children in intensive care
03

In context

Lead sponsor

Imperial College London is the lead sponsor of 824 studies on the registry; 178 are open to participants now.

Of its 9 completed or terminated interventional studies of FDA-regulated products, 6 (67%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
Up to 16 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Shocked children on PICU

Inclusion criteria

  • Any ventilated child requiring fluid bolus therapy on the PICU for clinical indications

Exclusion criteria

Exclusion Criteria:

  • Arrythmia
  • Intracardiac shunt
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
25 participants (actual)
Patient registry
No

Groups and cohorts

  • Children requiring fluid bolus on PICU

    Other: Ultrasound cardiac output measurement

Interventions

  • OtherUltrasound cardiac output measurement
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What researchers measure

Primary outcomes

  1. Fluid responsiveness

    10% increase in cardiac output following fluid bolus

    Time frame: Immediate

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Study locations

1 site
  • Imperial College Healthcare NHS Trust
    London, W2 1NY, United Kingdom
08

References and documents

Publications

  • McLean JRL, Inwald DP. The utility of stroke volume variability as a predictor of fluid responsiveness in critically ill children: a pilot study. Intensive Care Med. 2014 Feb;40(2):288-289. doi: 10.1007/s00134-013-3171-x. Epub 2013 Dec 5. No abstract available. PubMed 24306083 ↗
09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 8, 2019, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT01821742
Lead sponsor
Imperial College London
Responsible party
Sponsor
First posted
Apr 1, 2013
Start date
Mar 2013
Primary completion
Jul 2013
Completion
Jul 2013
Last update
Jul 8, 2019

Study contacts

David Inwald, MB BChir
principal investigator · Imperial College London

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jul 2019. You cannot join it, but the record below documents what was studied.

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