A Phase 2 interventional study of RBLF and RA in Rescue Therapy for Helicobacter Pylori, sponsored by Shanghai Jiao Tong University School of Medicine. Completed at 1 site in China. Open to participants aged 18 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2013-03-06.
Sponsored by Shanghai Jiao Tong University School of Medicine · Phase 2, Interventional, and Treatment
The eradication rates of first-line treatment for Helicobacter pylori(Hp) infection are not satisfactory. The study aims to compare the efficacy and safety between quadruple therapy with furazolidone and dual therapy with high doses of amoxicillin as rescue regimens for Hp.
6,687 studies on the registry are indexed under Infections; 807 are open to participants now.
This study's enrollment of 114 is close to the median of 120 across 4,200 interventional studies indexed under Infections.
Browse Infections studies →Shanghai Jiao Tong University School of Medicine is the lead sponsor of 358 studies on the registry; 104 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
receive a 14-day quadruple therapy,including rabeprazole(10mg bid),bismuth citrate(220mg bid),levofloxacin(200mg qm) and furazolidone(100mg bid).
Drug: RBLF
receive a 14-day dual therapy with high doses of rabeprazole(20mg bid) and amoxicillin(1000mg tid).
Drug: RA
The patients in Group RBLF will receive a 14-day quadruple therapy,including rabeprazole(10mg bid),bismuth citrate(220mg bid),levofloxacin(200mg qm) and furazolidone(100mg bid).
The patients in Group RA will be sent to a penicillin skin test before treatment except they were given penicillin before. They will receive a 14-day dual therapy with high doses of rabeprazole(20mg bid) and amoxicillin(1000mg tid).
13C-urea breath test
When the outcome of 13C-urea breath test is more than 4%, the helicobacter pylori infection is still exist(positive).
Time frame: 4 weeks after treatment
scale analysis of drug safety
Time frame: 4 weeks after treatment
13C-urea breath test
Time frame: baseline
This study is completed, as verified in Mar 2013. You cannot join it, but the record below documents what was studied.
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Shanghai Jiao Tong University School of Medicine