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TerminatedNCT01777789Updated Feb 9, 2016

The Role of Mid-Life Adiposity in Functional Brain Connectivity

An observational study in Alzheimer's Disease, sponsored by Medical College of Wisconsin. Terminated at 1 site in United States. Open to participants aged 45 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2016-02-09.

Sponsored by Medical College of Wisconsin · Observational

Why this study was terminated
This is a basic research study with no clinical data to report
Study type
Observational
Model
Case-control
Time perspective
Cross-sectional
Enrollment
60
Ages
45 Years to 65 Years
Sex
All
01

Study summary

The purpose of the study is to use functional MRI (fMRI) to measure brain connectivity in middle-aged individuals with different levels of body fat. The ultimate goal of this research is to develop an early diagnostic tool for Alzheimer's disease.

Read the detailed description

Participants will have one visit for:

  • Blood draw
  • Body composition scan
  • Cognitive screen
  • Neurological exam
  • MRI scan

The visit will take approximately 3 hours.

02

Conditions studied

  • Alzheimer's Disease

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Keywords

  • fMRI
  • Dementia
  • Alzheimer's disease
  • functional neuroimaging
  • Memory
03

In context

Alzheimer Disease

3,675 studies on the registry are indexed under Alzheimer Disease; 869 are open to participants now.

This study's enrollment of 60 is below the median of 200 across 751 observational studies indexed under Alzheimer Disease.

Browse Alzheimer Disease studies →

Lead sponsor

Medical College of Wisconsin is the lead sponsor of 540 studies on the registry; 120 are open to participants now.

Of its 71 completed or terminated interventional studies of FDA-regulated products, 56 (79%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
45 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Healthy volunteers from the community

Inclusion criteria

  • 45-65 years of age
  • Normal memory
  • Right-handed
  • General good physical health

Exclusion criteria

Exclusion Criteria:

  • History of stroke or neurological disease
  • Seizures or head injury with loss of consciousness within the last five years
  • Ferrous (magnetic) or electronic implants (due to the magnet in the MRI scanner)
  • Claustrophobia

More detailed inclusion/exclusion criteria must be met in order to qualify for the study. The study coordinator will determine eligibility.

05

Study design

Observational model
Case-control
Time perspective
Cross-sectional
Enrollment
60 participants (actual)
Patient registry
No
Biospecimen retention
Samples with dna
06

What researchers measure

Primary outcomes

  1. Brain connectivity measured by fMRI

    Time frame: One visit

07

Study locations

1 site
  • Medical College of Wisconsin/Froedtert Hospital
    Milwaukee, Wisconsin 53226, United States
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 9, 2016, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT01777789
Lead sponsor
Medical College of Wisconsin
Responsible party
Sponsor
First posted
Jan 29, 2013
Start date
Dec 2012
Primary completion
Feb 2016
Completion
Feb 2016
Last update
Feb 9, 2016

Study contacts

Piero Antuono, MD
principal investigator · Medical College of Wisconsin

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is terminated, as verified in Feb 2016. You cannot join it, but the record below documents what was studied.

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