An interventional study of Glutamine in Radiation Enteritis, sponsored by Nanjing University School of Medicine. Status unknown at 1 site in China. Open to participants aged 18 Years to 60 Years. Per ClinicalTrials.gov, last updated 2013-01-04.
Sponsored by Nanjing University School of Medicine · Not applicable, Interventional, and Treatment
Objective: To evaluate the effects of perioperative glutamine supplemented total parenteral nutrition support on nutritional status, immunologic function and intestinal permeability of patients with chronic radiation intestinal injury.
Methods: The 40 patients with CRII were randomized into two groups, the standard TPN group and glutamine-enriched TPN group. The patients were administered total parenteral nutrition for at least four weeks (two weeks pre-operation and two weeks post-operation). The nutritional status, immunologic function, plasma concentration of glutamine and intestinal permeability were measured at 1 day, 1 week and 2 weeks pre-operation, 3 day, 1 week and 2 weeks post-operation. Nutrition status was determined the plasma concentrations of hemoglobin, albumin, prealbumin, transferrin and triglyceride. Immunologic function were measured by the percentages of CD4+T cells and CD8+T cells, the ratio of CD4 +T cells to CD8+T cells ( CD4 +/CD8 +) was calculated， and serum IgA, IgM and IgG．The intestinal permeability was detected by the urinal ratio of lactulose and mannitol.
34 studies on the registry are indexed under Enteritis; 7 are open to participants now.
This study's planned enrollment of 30 is below the median of 53 across 26 interventional studies indexed under Enteritis.
Browse Enteritis studies →Nanjing University School of Medicine is the lead sponsor of 39 studies on the registry; 5 are open to participants now.
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Exclusion Criteria:
Drug: Glutamine
Drug: Glutamine
amino acid：1.2-2g/(kg·d) Glutamine：0.5g /(kg·d)
inflammatory factor
Time frame: 2 weeks after the surgery
This study is status unknown, as verified in Jan 2013. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Glutamine
Nanjing University School of Medicine