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CompletedNCT01741233VitDgenUpdated Aug 1, 2013

The Genetics Behind Vitamin D Status (VitDgen)

An interventional study of VitDgen in Vitamin D Deficiency, sponsored by Technical University of Denmark. Completed at 2 sites in Denmark. Open to participants aged 18 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2013-08-01.

Sponsored by Technical University of Denmark · Not applicable, Interventional, and Basic science

Phase
Not applicable
Study type
Interventional
Enrollment
102
Allocation
Not applicable
Ages
18 Years to 60 Years
Sex
All
01

Study summary

The overall purpose of the study is to investigate whether there is a relationship between 26 different single nucleotide polymorphisms (SNPs) in the vitamin D pathway, ultraviolet B (UV-B) irradiation of the skin and vitamin D status.

The hypothesis is that vitamin D status are influated by different genetic genotypes in the vitamin D pathway.

Read the detailed description

In this study approximately 80 participants (over 18 years) are included. All the participants has previously participated in the VitmaD intervention study (NCT01184716) .

Participants will in total receive 4 times UV-B irradiation (3 SED) with two day apart each time, to stimulate vitamin D production in the skin. The participants skintype will be measured. The study starts in January 2013 and runs to the end of Marts 2013. During this winter period, it is in Denmark not possible to produce vitamin D in the skin through sunlight exposure.

02

Conditions studied

  • Vitamin D Deficiency

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Keywords

  • SNPs
  • vitamin D
  • Vitamin D status
  • UVB irradiation
  • genetics
03

In context

Vitamin D Deficiency

784 studies on the registry are indexed under Vitamin D Deficiency; 61 are open to participants now.

This study's enrollment of 102 is above the median of 77 across 574 interventional studies indexed under Vitamin D Deficiency.

Browse Vitamin D Deficiency studies →

Lead sponsor

Technical University of Denmark is the lead sponsor of 10 studies on the registry; 1 is open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 60 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Health participants over 18 years, that previously participated in VitmaD intervention study

Exclusion criteria

Exclusion Criteria:

  • skindiseases
  • intake of medicin that causes photosensitive skin
  • pregnant or nursing
  • sun vacation 3 month before the intervention
  • intake of vitamin D supplement 3 month before the intervention
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
102 participants (actual)

Study arms

  • Experimental
    UV-B irraditation

    VitDgen

    Genetic: VitDgen

Interventions

  • GeneticVitDgen
06

What researchers measure

Primary outcomes

  1. serum 25-hydroxyvitamin D

    Measures the vitamin D status i serum at baseline and at the end of the project

    Time frame: 10 days

Secondary outcomes

  1. Skintest

    Optimize scientific; measures pigmentation and redness of the skin. Are measured at baseline and at end of project

    Time frame: 10 days

07

Study locations

2 sites
  • Bispebjerg Hospital
    Bispebjerg, Copenhagen 2400, Denmark
  • DTU / National Food Institute
    Mørkhøj, Søborg 2860, Denmark
08

References and documents

Publications

  • Nissen J, Vogel U, Ravn-Haren G, Andersen EW, Madsen KH, Nexo BA, Andersen R, Mejborn H, Bjerrum PJ, Rasmussen LB, Wulf HC. Common variants in CYP2R1 and GC genes are both determinants of serum 25-hydroxyvitamin D concentrations after UVB irradiation and after consumption of vitamin D(3)-fortified bread and milk during winter in Denmark. Am J Clin Nutr. 2015 Jan;101(1):218-27. doi: 10.3945/ajcn.114.092148. Epub 2014 Nov 5. PubMed 25527766 ↗
09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 1, 2013, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT01741233
Lead sponsor
Technical University of Denmark
Collaborators
Bispebjerg Hospital
Responsible party
Lone Banke Rasmussen (M.Sc., Ph.D., Technical University of Denmark) — Principal investigator
First posted
Dec 4, 2012
Start date
Nov 2012
Primary completion
Mar 2013
Completion
Mar 2013
Last update
Aug 1, 2013

Study contacts

Lone Rasmussen, M.Sc., Ph.D.
principal investigator · DTU, Denmark
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Dec 2012. You cannot join it, but the record below documents what was studied.

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