An interventional study of Mental stress and no intervention in Endothelial Function, sponsored by Johannes Gutenberg University Mainz. Completed at 1 site in Germany. Open to male participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2015-04-01.
Sponsored by Johannes Gutenberg University Mainz · Not applicable, Interventional, and Basic science
The purpose of this study is to determine whether interventions aimed at increasing sympathetic tone modify endothelial function measures as assessed by the measurement of flow-mediated dilation (FMD) and constriction (FMC). The investigators hypothesize that the three interventions under study will increase FMC while causing a blunting in FMD.
Further, the investigators plan to study the circadian variability of FMC and FMD. The investigators hypothesize a peak of FMD in the late hours of the day and a peak of FMC in the early hours.
Johannes Gutenberg University Mainz is the lead sponsor of 153 studies on the registry; 20 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Subjects will undergo endothelial function assessment at rest and, after a 45 minutes pause, 1 minute after begin of myogenic activation
Procedure: Myogenic activation
Subjects will undergo endothelial function assessment at rest and, after a 45 minutes pause, 1 minute after begin of cold pressure test
Procedure: Cold pressure test
Subjects will undergo endothelial function assessment at rest and, after a 45 minutes pause, 1 minute after begin of mental stress
Procedure: Mental stress
Control visit - no intervention performed - subjects will undergo endothelial function measurement twice at a distance of 45 minutes
Other: no intervention
Subjects will be asked to perform complex mathematic operations at a very fast pace
control visit
A pneumatic cuff will be inflated to suprasystolic pressure around both thighs and the subjects will be asked to perform plantar flexion exercises.
A hand will be placed in ice-cold water.
Change in FMD in response to sympathetic activation
Flow-mediated dilation will be measured at rest and during each of the interventions.
Time frame: Change in FMD before versus 1 Minute after begin of intervention
Change in FMC during sympathetic activation
Change in Flow-mediated constriction induced by each of the interventions.
Time frame: Change in FMC before versus 1 minute after begin of each intervention
This study is completed, as verified in Mar 2015. You cannot join it, but the record below documents what was studied.
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Johannes Gutenberg University Mainz