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CompletedNCT01693744Updated Sep 26, 2012

Pseudoexfoliation and Chronic Kidney Disease

An observational study in Chronic Kidney Disease, sponsored by Corum State Hospital. Completed at 1 site in Turkey. Open to participants aged 40 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2012-09-26.

Sponsored by Corum State Hospital · Observational

Study type
Observational
Model
Case-control
Time perspective
Prospective
Enrollment
358
Ages
40 Years to 80 Years
Sex
All
01

Study summary

Background: Pseudoexfoliation (PEX) is characterised by the deposition of fibrillar material in an eye structures and many other parts of the body including kidneys and blood vessels. As both PEX and chronic kidney disease (CKD) are associated with oxidative stress and endothelial dysfunction we studied if the risk of PEX was increased in patients with CKD.

Methods: Patients over age 40 with the diagnosis of CKD were included in the study. Chronic kidney disease was diagnosed as decreased glomerular filtration rate (GFR) of less than 60 mL/min/1.73 m². Study groups were arranged as group 1 consisting of HD receiving patients, group 2 consisting of stage 1-4 CKD patients and group 3 consisting of patients with normal kidney functions (control group). Demographic properties and the rate of PEX were evaluated and compaired between the groups.

02

Conditions studied

  • Chronic Kidney Disease

Keywords

  • Pseudoexfoliation, chronic kidney disease
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In context

Kidney Diseases

3,840 studies on the registry are indexed under Kidney Diseases; 500 are open to participants now.

This study's enrollment of 358 is above the median of 192 across 1,033 observational studies indexed under Kidney Diseases.

Browse Kidney Diseases studies →

Lead sponsor

This is the only study on the registry with Corum State Hospital as lead sponsor.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
40 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Probability sample

Study population

Patients from nephrology clinic

Inclusion criteria

  • All patients with chronic kidney disease stage 1-5

Exclusion criteria

Exclusion Criteria:

  • History of eye trauma or surgery
05

Study design

Observational model
Case-control
Time perspective
Prospective
Enrollment
358 participants (actual)

Groups and cohorts

  • Dialysis patients

    Patients with stage 5 chronic kidney disease undergoing haemodialysis

  • Chronic kidney disease patients

    Stage 1-4 Chronic kidney disease patients

  • Control group

    Patients with normal renal functions

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What researchers measure

Primary outcomes

  1. Prevalance of pseudoexfoliation in patients with chronic kidney disease

    Time frame: 7 months

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Study locations

1 site
  • Corum State Hospital
    Corum, 19000, Turkey
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 26, 2012, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT01693744
Lead sponsor
Corum State Hospital
Responsible party
Leyla Niyaz (Ophthalmology Specialist, Corum State Hospital) — Principal investigator
First posted
Sep 26, 2012
Start date
Oct 2011
Completion
Apr 2012
Last update
Sep 26, 2012

Study contacts

Leyla Niyaz, M.D.
principal investigator · Specialist in Ophthalmology

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Sep 2012. You cannot join it, but the record below documents what was studied.

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