A Phase 1 interventional study of Embryo selection based on polscope grading or morphology in Infertility, sponsored by Hadassah Medical Organization. Withdrawn at 1 site in Israel. Open to female participants aged 18 Years to 38 Years. Per ClinicalTrials.gov, last updated 2015-08-20.
Sponsored by Hadassah Medical Organization · Phase 1 and Interventional
Selecting one or two IVF embryos with the highest potential to implant is extremely important for the success of the treatment- obtaining pregnancies and avoiding multi-fetal gestations. The currently used IVF embryo grading method is based solely on embryo morphology (cleavage rate and fragmentation) just before the transfer, which is not very well correlated with the implantation potential of each embryo. Oocyte quality and adequacy are the most important factors determining the biological quality and implantation potential of the embryo. It impossible to grade oocytes using plain optical systems, other than maturity and gross anomalies.
Polscope systems allow to visualize intra ooplasmic structures and determine their retardance, as well as that of the Zona Pellucida. The investigators hypothesize that grading embryos using the oocyte's parameters as visualized by polscope is superior to conventional morphology and correlates better with their implantation potential.
Here the investigators will perform a prospective randomized controlled trial to examine this hypothesis.
Each embryo will be graded in accordance to polscope based parameters; the presence of a spindle in the oocyte, its retardance, the distance between the spindle and the PB, and the thickness and retardance of the ZP.
In the experimental group the embryos for transfer will be selected based on these parameters, whereas in the control group they will be selected based on conventional morphologic criteria.
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Exclusion Criteria:
Embryos for transfer will be selected based on highest polscope scores, unless are not grade 1-2 by conventional morphology
Procedure: Embryo selection based on polscope grading or morphology
Conventional embryo grading and decision making
Procedure: Embryo selection based on polscope grading or morphology
In the experimental arm embryo grading will be performed by polscope rather than conventional morphology, and the best embryo/s for transfer will be selected by this method.
Occurrence of clinical pregnancy
Time frame: within 2 weeks after ET
Live birth
Time frame: up to 40 weeks
This study is withdrawn, as verified in May 2012. You cannot join it, but the record below documents what was studied.
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Hadassah Medical Organization