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CompletedNCT01595815Updated May 9, 2025

Successful Pregnancy and Delivery After AOA

An interventional study of Calcium ionophore and Strontium chloride (SrCl2) in Infertility, sponsored by Maria Fertility Hospital. Completed at 1 site in Korea, Republic of. Open to female participants aged 20 Years to 45 Years. Per ClinicalTrials.gov, last updated 2025-05-09.

Sponsored by Maria Fertility Hospital · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
100
Allocation
Non-randomized
Ages
20 Years to 45 Years
Sex
Female
01

Study summary

Artificial oocyte activation with strontium chloride or calcium ionophore improves fertilization, embryo quality, pregnancy and delivery rate in women who showed complete fertilization failure or low fertilization rates

02

Conditions studied

  • Infertility

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Keywords

  • Fertilization failure, calcium ionophore, SrCl2
03

In context

Infertility

2,506 studies on the registry are indexed under Infertility; 407 are open to participants now.

This study's enrollment of 100 is below the median of 120 across 1,698 interventional studies indexed under Infertility.

Browse Infertility studies →

Lead sponsor

Maria Fertility Hospital is the lead sponsor of 2 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
20 Years to 45 Years
Sexes eligible
Female
Accepts healthy volunteers
No

Inclusion criteria

  • Fertilization rate was less than 30% after conventional ICSI.
  • Fertilization rate was less than 50% after ICSI with calcium ionophore.
  • Repeated complete fertilization failure or low fertilization rates following ICSI in previous cycles

Exclusion criteria

Exclusion Criteria:

  • Fertilization rate was more than 30% after conventional ICSI
  • Fertilization rate was more than 50% after ICSI with calcium ionophore.
  • Successful pregnancy and delivery after ICSI in previous cycles
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Non-randomized
Intervention model
Parallel assignment
Enrollment
100 participants (actual)

Study arms

  • Active comparator
    Conventional ICSI

    The couple showed complete fertilization failure after ICSI.

    Other: Calcium ionophore · Other: Strontium chloride (SrCl2)

  • Active comparator
    Convention ICSI

    The couple showed a low fertilization rates after ICSI.

    Other: Calcium ionophore · Other: Strontium chloride (SrCl2)

Interventions

  • OtherCalcium ionophore

    Oocytes were activated with calcium ionophore after ICSI

  • OtherStrontium chloride (SrCl2)

    Oocytes were activated with strontium chloride after ICSI

06

What researchers measure

Primary outcomes

  1. Fertilization rate

    Time frame: 18 hours

Secondary outcomes

  1. Embryo quality

    Time frame: 3 Days

  2. Pregnancy and Implantation rates

    Time frame: 2 months

  3. Assessment of Infant health care

    This assessment is according to the standard set by the National Health Insurance Service (NHIS) in Korea.

    Time frame: birth and at 3, 6, 12, 24, 36, 60, and 72 months

07

Study locations

1 site
  • Maria Fertility Hospital
    Seoul, 138-160, Korea, Republic of
08

References and documents

Publications

  • Kim JW, Yang SH, Yoon SH, Kim SD, Jung JH, Lim JH. Successful pregnancy and delivery after ICSI with artificial oocyte activation by calcium ionophore in in-vitro matured oocytes: a case report. Reprod Biomed Online. 2015 Apr;30(4):373-7. doi: 10.1016/j.rbmo.2014.11.014. Epub 2014 Dec 11. PubMed 25592974 ↗
09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 9, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT01595815
Lead sponsor
Maria Fertility Hospital
Responsible party
Jun-Woo Kim, Principal Investigator (Maria Fertility Hospital, Maria Fertility Hospital) — Principal investigator
First posted
May 10, 2012
Start date
May 2007
Primary completion
Sep 2011
Completion
Apr 2014
Last update
May 9, 2025

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jan 2014. You cannot join it, but the record below documents what was studied.

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