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CompletedNCT01594775Updated Feb 25, 2014

Oxytocin, Couple Interaction and Wound Healing

A Phase 1 interventional study of Syntocinon (Oxytocin) nasal spray and Placebo in Healthy Volunteers, sponsored by University of Zurich. Completed at 1 site in Switzerland. Open to participants aged 21 Years to 45 Years. Per ClinicalTrials.gov, last updated 2014-02-25.

Sponsored by University of Zurich · Phase 1, Interventional, and Treatment

Phase
Phase 1
Study type
Interventional
Enrollment
160
Allocation
Randomized
Ages
21 Years to 45 Years
Sex
All
01

Study summary

effects of intranasal oxytocin and couple interaction on wound healing.

  • Trial with medicinal product
02

Conditions studied

  • Healthy Volunteers
03

In context

Lead sponsor

University of Zurich is the lead sponsor of 1,030 studies on the registry; 130 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
21 Years to 45 Years
Sexes eligible
All
Accepts healthy volunteers
No

Eligibility criteria

Inclusion criteria:

  • healthy heterosexual couples
  • in a stable relationship since > 1 year

Exclusion criteria: pregnancy

  • breast feeding
  • heavy smoking (> 5 cigarettes/d)
  • extensive skin disease
  • artificial UV irradiation during \< 3 months before study inclusion
05

Study design

Phase
Phase 1
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Investigator)
Enrollment
160 participants (actual)

Study arms

  • Active comparator
    nasal spray

    Drug: Syntocinon (Oxytocin) nasal spray

  • Placebo comparator
    Placebo

    Drug: Placebo

Interventions

  • DrugSyntocinon (Oxytocin) nasal spray

    two-times daily self-administration of nasal spray containing active substance (oxytocin) during five days after wounding.

  • DrugPlacebo

    two-times daily self-administration of nasal spray containing placebo during five days after wounding.

06

What researchers measure

Primary outcomes

  1. wound size

    wound healing process within seven days after wounding

    Time frame: seven days

07

Study locations

1 site
  • University Hospital Zurich, Dept. of Dermatology
    Zurich, 8091, Switzerland
08

References and documents

Publications

  • Doerr JM, Klaus K, Troxel W, Nater UM, Bodenmann G, Heinrichs M, Ehlert U, Ditzen B. The Effect of Intranasal Oxytocin on the Association Between Couple Interaction and Sleep: A Placebo-Controlled Study. Psychosom Med. 2022 Jul-Aug 01;84(6):727-737. doi: 10.1097/PSY.0000000000001091. Epub 2022 Apr 27. PubMed 35472193 ↗
09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 25, 2014, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT01594775
Lead sponsor
University of Zurich
Collaborators
Swiss National Science Foundation
Responsible party
Sponsor
First posted
May 9, 2012
Start date
Oct 2011
Primary completion
Oct 2013
Completion
Oct 2013
Last update
Feb 25, 2014

Study contacts

01 Studienregister MasterAdmins
study director · UniversitaetsSpital Zuerich
Severin Laeuchli, MD
principal investigator · University Hospital Zurich, Division of Dermatology
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Feb 2014. You cannot join it, but the record below documents what was studied.

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