An observational study in Infertility, sponsored by Origio A/S. Terminated at 2 sites in United Kingdom. Open to female participants aged 18 Years to 40 Years. Per ClinicalTrials.gov, last updated 2013-05-08.
Sponsored by Origio A/S · Observational
The purpose of this study is to develop an algorithm for embryo selection based on amino acid profiling (AAP) of spent culture medium. Development of the algorithm will be based on the ongoing implantation rate of the individual embryos transferred. As evaluated by ultrasound scan in gestational week 7.
IVF/ICSI treatment has permitted many thousands of couples to conceive worldwide yet is limited by low success rates (in UK, approx. 25% live birth rate/treatment cycle for women up to 42 years of age; HFEA Annual Report, 2006) and a confounding high multiple birth rate (23%) due to the transfer of more than a single pre-implantation embryo. Multiple births are associated with prematurity, increased neonatal and maternal mortality and child handicap as well as being a major burden for health care systems. These problems have been highlighted in the data published by the HFEA (2009), which has called for "a professionally-led, coordinated national strategy to reduce the number of multiple births". This challenge could be met if single embryos of known developmental competence could be selected for transfer, thereby making the embryo selection process even more crucial. However, current non-invasive embryo selection criteria using light microscope analysis have limited predictive value for ongoing pregnancy.
2,506 studies on the registry are indexed under Infertility; 407 are open to participants now.
This study's enrollment of 10 is below the median of 200 across 714 observational studies indexed under Infertility.
Browse Infertility studies →Origio A/S is the lead sponsor of 2 studies on the registry; none are open to participants now.
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Subjects will be recruited from couples and single women attending the IVF clinic for IVF/ICSI treatment.
Exclusion Criteria:
Subjects undergoing IVF or ICSI treatment with a maximum of 2 embryos transferred
Amino acid profile
Amino acid profiling (AAP) will be performed of spent culture medium from individually cultured embryos. AAP results will be correlated to the ongoing implantation rate week 7 as well as morphological embryo development parametres.
Time frame: After 24 hours of culture
Ongoing clinical pregnancy rate
Evaluated by ultrasound scan
Time frame: Gestational week 7
This study is terminated, as verified in May 2013. You cannot join it, but the record below documents what was studied.
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Origio A/S