An interventional study of Weight loss and Soy in Obesity, sponsored by McMaster University. Completed at 1 site in Canada. Open to participants aged 35 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2015-06-09.
Sponsored by McMaster University · Not applicable, Interventional, and Treatment
It is known that dieting (restricted energy intake) without resistance training leads to a reduced metabolic rate, and the loss of both fat and muscle mass. When exercise is not included in a period of restricted energy intake, the degree to which muscle mass is lost is highly dependent upon protein consumption. Whey protein is a high quality protein isolated from milk and is known to stimulate new protein synthesis for all proteins in your body. Previous research has established that the consumption of whey protein has been correlated with retaining muscle mass while stimulating fat loss. However, the mechanisms behind these findings is still unknown. The purpose of this study is to establish a mechanistic underpinning to the efficacy of whey protein versus soy protein and a carbohydrate control (maltodextrin), in promoting fat mass loss and lean mass retention during a period of short-term controlled dietary energy deficit (-750 kcalories/day).
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This study's enrollment of 42 is below the median of 73 across 3,175 interventional studies indexed under Overweight.
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Of its 6 completed or terminated interventional studies of FDA-regulated products, 2 (33%) have results posted.
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Exclusion Criteria:
Carbohydrate \& 750 kcal dietary restriction while they receive a daily supplement (2 x 25 g) of maltodextrin (no protein) for 14 days. Weight loss.
Behavioral: Weight loss
Whey protein \& 750 kcal dietary restriction while they receive a daily supplement (2 x 25 g) of WPI for 14 days. Weight loss.
Behavioral: Weight loss · Dietary Supplement: Whey
Soy protein \& 750 kcal dietary restriction while they receive a daily supplement (2 x 25 g) of SPC for 14 days. Weight loss.
Behavioral: Weight loss · Dietary Supplement: Soy
-750kcal/d
2 x 25g/d SPC
2 x 25g/d WPI
Muscle protein synthesis rate and lipolytic rate as measured using stable isotope and glycerol infusions.
Time frame: After 14 day dietary intervention
Transcriptomic changes (via gene profiling) associated with the effects of whey on lipogenic and lipid oxidative genes, and protein synthetic pathways in muscle.
Time frame: After 14 days of dietary intervention
This study is completed, as verified in Jun 2015. You cannot join it, but the record below documents what was studied.
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McMaster University