An interventional study of endovascular sampling in Acute Stroke, sponsored by University of Southern California. Terminated at 2 sites in United States. Open to participants aged 40 Years to 95 Years. Per ClinicalTrials.gov, last updated 2017-08-01.
Sponsored by University of Southern California · Not applicable, Interventional, and Diagnostic
This investigation will address the safety and feasibility of distal, intra-arterial sampling through endovascular access, in acute stroke patients. Levels of Magnesium will be measured in the region of infarct in patients who had been treated with intravenous Magnesium therapy following an acute stroke. This study attempts to address whether the traditional intravenous means of neuroprotectant administration achieves adequate concentration of the therapeutic agent in the area of diseased tissue.
7,286 studies on the registry are indexed under Stroke; 2,007 are open to participants now.
This study's enrollment of 2 is below the median of 50 across 5,369 interventional studies indexed under Stroke.
Browse Stroke studies →University of Southern California is the lead sponsor of 773 studies on the registry; 135 are open to participants now.
Of its 68 completed or terminated interventional studies of FDA-regulated products, 32 (47%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Paired sampling from the distal arterial(endovascular catheter) and peripheral venous (femoral sheath) locations in acute stroke patients undergoing endovascular recanalization who received intravenous Magnesium Sulfate as a part of the FAST-MAG study
Other: endovascular sampling
Paired sampling from the distal arterial(endovascular catheter) and peripheral venous (femoral sheath) locations: withdrawal of 3ml of blood from vasculature distal to the occlusive thrombus
Magnesium concentration
The primary endpoint is the relative concentration of Mg in the core cerebral ischemic zone, compared to systemic therapeutic Mg levels, as a measure of delivery efficacy of systemic administration.
Time frame: intra-procedure (at time of first pass of retrieval device)
Sampling feasibility
sampling feasibility will be determined by the proportion of cases in which a cerebral circulation Mg level was successfully assayed
Time frame: intra-procedural (at time of first pass of retrieval device)
Safety
safety will be assessed by intraoperative adverse events, postoperative neurologic examination including NIH stroke scale, and postoperative brain imaging.
Time frame: post-operative day 1
Plan to share: No
No publications or documents are linked to this record.
This study is terminated, as verified in Jul 2017. You cannot join it, but the record below documents what was studied.
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University of Southern California