An interventional study of Magnesium Sulfate and Ketamine in Intubating Condition, sponsored by Seoul National University Bundang Hospital. Completed at 1 site in Korea, Republic of. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2012-08-27.
Sponsored by Seoul National University Bundang Hospital · Not applicable and Interventional
In this study, methods which are known for facilitating rapid sequence intubation or accelerating rocuronium (Roc)onset are compared including magnesium (Mg), ketamine pretreatment, large dose rocuronium and priming.
Patients are pretreated with Mg, ketamine, or priming dose Roc. Two groups do not receive pretreatment, but are given Roc 0.6 mg/kg or 0.9 mg/kg.
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This study's enrollment of 110 is above the median of 80 across 732 interventional studies indexed under Disease.
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Exclusion Criteria:
Patients receive ketamine 0.5 mg/kg 2 min before Roc injection.
Drug: Ketamine
Patients receive Roc 0.06 mg/ kg as a priming dose 3 min before injection of Roc 0.54 mg/kg.
Drug: rocuronium
Patients receive Roc 0.9 mg/kg as an induction dose.
Patients receive Roc 0.6 mg/kg without any pretreatments of Mg, ketamine, or priming.
Patients receive magnesium sulfate (MgSO4) 50 mg/kg over 10 min before Roc injection.
Drug: Magnesium Sulfate
Patients receive MgSO4 50 mg/kg for 10 min before injection of Roc 0.6 mg/kg.
patients receive ketamine 0.5 mg/kg 2 min before Roc injection.
Patients receive Roc 0.06 mg/ kg as a priming dose 3 min before injection of Roc 0.54 mg/kg.
Intubation score
Patients are tracheally intubated, and intubation scores(poor, good,excellent)are rated.
Time frame: participants will be followed at the time point of intubation, an expected average of 70 sec from the start of rocuronium injection.
Roc duration
Time from the start of rocuronium injection until reappearance of two muscle twitches in TOF stimulations is measured, using ToF-Watch sx.
Time frame: participants will be followed when TOF count reaches two, an expected average of 40 min.
Roc onset
Time from the start of rocuronium injection until TOF count=0 using TOF-Watch sx.
Time frame: participants will be followed when TOFcount =0 within an expected average of 4 min from the start of rocuronium injection.
Hemodynamic variables
Mean arterial pressure (MAP)and heart rate (HR) are measured at baseline, before intubation, and 1, 2, 3, 4, 5 min after intubation.
Time frame: participants will be followed at baseline, before and for 5 min after the intubation, an expected average of 8 min after the start of anesthetic induction.
TOF% at intubation
neumeric value expressed as %, displayed on the monitor of TOF watch-Sx in TOF stimulation (ex. 5% on the display means 95% suppression of T1)
Time frame: participants will be followed at the time point of intubation, an expected average of 70 sec from the start of rocuronium injection.
This study is completed, as verified in Aug 2012. You cannot join it, but the record below documents what was studied.
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Seoul National University Bundang Hospital