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CompletedNCT01405092Updated Aug 8, 2012

Continuous Versus Conventional Volume Management During CRRT (Continuous Renal Replacement Therapy)

An interventional study of use of continuous renal replacement machine for renal replacement and use of blood volume monitoring device in conjunction with machine used for continuous renal replacement to assess and determine volume removal in Continuous Renal Replacement Therapy, sponsored by Dallas VA Medical Center. Completed at 1 site in United States. Open to participants aged 21 Years and older. Per ClinicalTrials.gov, last updated 2012-08-08.

Sponsored by Dallas VA Medical Center · Not applicable, Interventional, and Supportive care

Phase
Not applicable
Study type
Interventional
Enrollment
28
Allocation
Randomized
Ages
21 Years and older
Sex
All
01

Study summary

Use of on-line blood volume monitoring during continuous renal replacement therapy can improve volume management in acute kidney injury patients requiring renal replacement

02

Conditions studied

  • Continuous Renal Replacement Therapy

Keywords

  • volume
  • acute kidney injury
  • continuous renal replacement
03

In context

Lead sponsor

Dallas VA Medical Center is the lead sponsor of 28 studies on the registry; 1 is open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
21 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Patients with kidney injury requiring continuous renal replacement therapy and volume removal

Exclusion criteria

Exclusion Criteria:

  • unable to provide or obtain patient consent
  • not expected to survive 48 hours
05

Study design

Phase
Not applicable
Primary purpose
Supportive care
Allocation
Randomized
Intervention model
Crossover assignment
Masking
None (open label)
Enrollment
28 participants (actual)

Study arms

  • Placebo comparator
    Standard volume management

    patients on this arm will receive usual care volume management during continuous renal replacement therapy

    Device: use of continuous renal replacement machine for renal replacement

  • Active comparator
    continuous volume management

    use of Critline, Hemametrics USA, in conjunction with continuous renal replacment therapy to determine volume removal

    Device: use of continuous renal replacement machine for renal replacement · Device: use of blood volume monitoring device in conjunction with machine used for continuous renal replacement to assess and determine volume removal

Interventions

  • Deviceuse of continuous renal replacement machine for renal replacement

    usual care with volume removal during continuous renal replacement therapy

  • Deviceuse of blood volume monitoring device in conjunction with machine used for continuous renal replacement to assess and determine volume removal

    blood volume monitoring device, Critline, Hemametric, USA, will be used in conjunction with continuous renal replacement to determine rate of volume removal

06

What researchers measure

Primary outcomes

  1. compare number of hypotensive events in treatment versus control arms

    compare the number of hypotensive events during use of crit-line monitor over 24 hour period versus during control 24 hour period

    Time frame: 24 hour for each arm

07

Study locations

1 site
  • Dallas VA Medical Center
    Dallas, Texas 75216, United States
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 8, 2012, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT01405092
Lead sponsor
Dallas VA Medical Center
Responsible party
Devasmita C. Dev MD (Director of In-center and Home Dialysis, Dallas VA Medical Center) — Principal investigator
First posted
Jul 29, 2011
Start date
Apr 2010
Primary completion
Aug 2012
Completion
Aug 2012
Last update
Aug 8, 2012

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Aug 2012. You cannot join it, but the record below documents what was studied.

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