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CompletedNCT01403844Updated May 20, 2020

Carotenoid Response to the Intake of Vegetables and Fruits

An interventional study of Carotenoid Depletion and Carotenoid Repletion in Resonance Raman Spectroscopy for Dietary Carotenoid Intake, sponsored by USDA Grand Forks Human Nutrition Research Center. Completed at 1 site in United States. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-05-20.

Sponsored by USDA Grand Forks Human Nutrition Research Center · Not applicable, Interventional, and Basic science

Phase
Not applicable
Study type
Interventional
Enrollment
29
Allocation
Not applicable
Ages
18 Years to 65 Years
Sex
All
01

Study summary

The purpose of this study is to validate the non-invasive tool, resonance Raman spectroscopy for assessing vegetable and fruit consumption.

Read the detailed description

This study will validate the use of resonance Raman spectroscopy to assess vegetable and fruit intake by performing a controlled feeding study during which volunteers will consume a provided diet with known amounts of carotenoids in the form of fruits and vegetables.

02

Conditions studied

  • Resonance Raman Spectroscopy for Dietary Carotenoid Intake

Keywords

  • resonance Raman spectroscopy
  • Dietary Guidelines
  • fruits
  • biomarkers
  • carotenoids
  • MyPlate
  • vegetables
03

In context

Lead sponsor

USDA Grand Forks Human Nutrition Research Center is the lead sponsor of 58 studies on the registry; 3 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • Men and women aged 18 - 65 years
  • Weight stable (±5 lbs) for at least 2 months prior to the start of the study
  • Body mass index (BMI) between 19-30 kg/m2
  • Willing to refrain from the use of nicotine and dietary supplements for the duration of the study
  • Willing to maintain baseline weight and physical activity levels

Exclusion criteria

Exclusion Criteria:

  1. BMI greater than 30.
  2. Gastrointestinal disorders, disease, or medication that affects carotenoid absorption or storage
  3. Current smoker
  4. Allergies or intolerances to foods to be utilized in the study
  5. Consumption of greater than an average of 1 alcoholic drink/day for women and 2/day for men, use of nutritional/sports supplements (if unwilling to discontinue during the study)
  6. Pregnancy or lactating
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
29 participants (actual)

Study arms

  • Other
    Skin Carotenoids

    Skin carotenoids will be measured under conditions of depletion or repletion

    Other: Carotenoid Depletion · Other: Carotenoid Repletion · Other: Natural Repletion

Interventions

  • OtherCarotenoid Depletion

    Depletion of carotenoids using a restricted food list

  • OtherCarotenoid Repletion

    Carotenoid repletion with provided diet based on dietary guidelines.

  • OtherCarotenoid Depletion

    Carotenoid depletion using a restricted food list.

  • OtherNatural Repletion

    Resumption of usual personal diet regimen. No restrictions.

06

What researchers measure

Primary outcomes

  1. Serum and skin levels of carotenoids in adults fed a high carotenoid diet

    Time frame: 28 weeks

07

Study locations

1 site
  • Grand Forks Human Nutrition Research Center
    Grand Forks, North Dakota 58203, United States
08

References and documents

Publications

  • Jahns L, Johnson LK, Mayne ST, Cartmel B, Picklo MJ Sr, Ermakov IV, Gellermann W, Whigham LD. Skin and plasma carotenoid response to a provided intervention diet high in vegetables and fruit: uptake and depletion kinetics. Am J Clin Nutr. 2014 Sep;100(3):930-7. doi: 10.3945/ajcn.114.086900. Epub 2014 Jul 9. PubMed 25008856 ↗

Individual participant data

Plan to share: No

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 20, 2020, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT01403844
Lead sponsor
USDA Grand Forks Human Nutrition Research Center
Responsible party
Sponsor
First posted
Jul 27, 2011
Start date
Jun 2011
Primary completion
Sep 2012
Completion
Sep 2012
Last update
May 20, 2020

Study contacts

James Roemmich, PhD
principal investigator · USDA Grand Forks Human Nutrition Research Center

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in May 2020. You cannot join it, but the record below documents what was studied.

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