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WithdrawnNCT01402752Updated Jun 18, 2026

System for Measuring Non-invasive Blood Flow in the Tracheobronchial Mucosa: Validation of Reproducibility

An interventional study of Blood flow to the tracheo-bronchial mucosa in Healthy, sponsored by Centre Hospitalier Universitaire de Nīmes. Withdrawn. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-06-18.

Sponsored by Centre Hospitalier Universitaire de Nīmes · Not applicable, Interventional, and Diagnostic

Why this study was withdrawn
20131209 Regulatory authorization is currently blocked at the ANSM.
Phase
Not applicable
Study type
Interventional
Enrollment
0
Allocation
Not applicable
Ages
18 Years and older
Sex
All
01

Study summary

The primary objective of this study is to evaluate the reproducibility of a method of measuring blood flow rates to the tracheo-bronchial mucosa using diluted dimethyl ether as a tracer.

02

Conditions studied

  • Healthy
03

In context

Lead sponsor

Centre Hospitalier Universitaire de Nīmes is the lead sponsor of 587 studies on the registry; 96 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • The patient must have given his/her informed and signed consent
  • The patient must be insured or beneficiary of a health insurance plan

Exclusion criteria

Exclusion Criteria:

  • The patient is under judicial protection, under tutorship or curatorship
  • The patient refuses to sign the consent
  • It is impossible to correctly inform the patient
  • Patient is pregnant
  • Patient is breast feeding
  • The patient is a smoker
  • The patient has, or has a history of, chronic respiratory insufficiency
  • The patient has a contra-indication for a treatment necessary in this study
05

Study design

Phase
Not applicable
Primary purpose
Diagnostic
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
0 participants (actual)

Study arms

  • Experimental
    All patients

    All patients included in this study according to stated inclusion and exclusion criteria.

    Biological: Blood flow to the tracheo-bronchial mucosa

Interventions

  • BiologicalBlood flow to the tracheo-bronchial mucosa

    Measurement of blood flow to the tracheo-bronchial mucosa via differential absorption of diluted dimethyl ether tracer gas.

06

What researchers measure

Primary outcomes

  1. The reproducibility of two measures of Qaw at a five minute interval

    Qaw is the blood flow measured in the tracheobronchial mucosa. Qaw = VDME/(FDME\*alpha\*10s) where VDME is the volume of dimethyl-ether exhaled (ml), FDME is the mean concentration of dimethyl-ether (%), alpha is the Bunsen coefficient for the dissolution of dimethyl ether in tissues and blood at 37°C (i.e. 9ml/ml).

    Time frame: Five minutes

Secondary outcomes

  1. The time necessary to complete one measure of Qaw (minutes)

    Qaw = blood flow measured in the tracheobronchial mucosa

    Time frame: Day 1

07

Study locations

No study locations are listed for this record.

08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 18, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT01402752
Lead sponsor
Centre Hospitalier Universitaire de Nīmes
Responsible party
Sponsor
First posted
Jul 26, 2011
Start date
Nov 2013
Primary completion
Mar 2014 (estimated)
Completion
Mar 2014 (estimated)
Last update
Jun 18, 2026

Study contacts

Charles Le Merre, MD
principal investigator · Centre Hospitalier Universitaire de Nīmes

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is withdrawn, as verified in Jun 2017. You cannot join it, but the record below documents what was studied.

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