An interventional study of Hops Extract and Placebo (silica) in Mood Modulation and Modulation of Cognition, sponsored by Northumbria University. Completed at 1 site in United Kingdom. Open to participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2012-06-25.
Sponsored by Northumbria University · Not applicable, Interventional, and Basic science
Hops have been used for many years for their supposed sedative and anxiety reducing properties and can be found in many natural remedies for stress, anxiety and sleeping that are already available to buy.
However, human trials investigating the effects of hops have so far been limited to the effects of the combination of hops and valerian in relation to sleep. Such studies have identified that a valerian-hops mixture can result in improved sleep but Valerian alone has no effect.
The current study aims to investigate the effect of hops alone in healthy human participants aged 18-35 years.
Northumbria University is the lead sponsor of 156 studies on the registry; 22 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Equivalent to 0.5g dry weight
Dietary Supplement: Hops Extract
Equivalent to 2g dry weight
Dietary Supplement: Hops Extract
Equivalent to 0.5g dry weight
Dietary Supplement: Hops Extract
Equivalent to 2g dry weight
Dietary Supplement: Hops Extract
Other: Placebo (silica)
All 150 participants will complete 1 study visit; receiving either of the 4 hops doses or placebo (silica). Computer generated random numbers will be used to allocate treatments to participant identification numbers. Treatment will be administered in capsule form and in a double blind manner.
All 150 participants will complete 1 study visit; receiving either of the 4 hops doses or placebo (silica). Computer generated random numbers were used to allocate treatments to participant identification numbers. Treatment will be administered in capsule form and in a double blind manner.
Mood
* Mood as assessed by STAI, Bond-Lader mood scales, POMS, DEQ and stress/euphoria/sedation visual analogue scales (VAS). * The shift in mood (STAI, Bond-Lader, POMS, DEQ, Stress/Euphoria/Sedation VAS) inculcated by completion of cognitive tasks. * Heart rate and blood pressure. * The modulation of blood pressure and heart rate inculcated by completion of cognitive tasks.
Time frame: across 3 hours
Satiety
* Satiety as assessed by VAS (hungry/full/desire to eat/food intake). * The modulation of satiety (VAS) inculcated by completion of the cognitive tasks.
Time frame: across 3 hours
Bioavailability of Hops
• Plasma hops levels are to be examined to assess bioavailability.
Time frame: across 3 hours
Cognition
* Performance on working memory tasks (2-back and logical reasoning). * Performance on serial subtraction element of a dual task. * Performance on word and picture recognition tasks.
Time frame: across 3 hours
This study is completed, as verified in Jun 2012. You cannot join it, but the record below documents what was studied.
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Northumbria University