A Phase 1/2 interventional study of Essential Amino Acids and Endurance exercise in Muscle Loss and Muscle Anabolism, sponsored by United States Army Research Institute of Environmental Medicine. Completed at 2 sites in United States. Open to participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2017-07-21.
Sponsored by United States Army Research Institute of Environmental Medicine · Phase 1/2, Interventional, and Basic science
The modern warfighter faces numerous physiological challenges including sleep deprivation, sustained intense physical activity, and caloric restriction, the combined effects of which may result in the loss of lean body mass and decreased physical performance. Dietary interventions may help preserve lean body mass and facilitate recovery from periods of intense physical demand. For example, dietary strategies that increase amino acid availability have been shown to stimulate protein synthesis in skeletal muscle following resistance exercise. Because military tasks also incorporate endurance exercise components, studies regarding the effects of increasing dietary amino acids following endurance exercise are warranted. The objectives of this study are to characterize the effect of endurance exercise on protein synthesis and breakdown as well as the ability of an essential amino acid supplement to influence skeletal muscle protein metabolism and its cellular and molecular regulation following endurance exercise.
United States Army Research Institute of Environmental Medicine is the lead sponsor of 67 studies on the registry; 9 are open to participants now.
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Muscle protein turnover and intracellular signaling are measured at rest for comparison to post-exercise muscle metabolism.
Post-exercise muscle protein metabolism was measured to determine if endurance exercise affects muscle metabolism compared to rest.
Dietary Supplement: Essential Amino Acids · Other: Endurance exercise
Muscle metabolism response to endurance exercise with essential amino acid supplementation
Dietary Supplement: Essential Amino Acids
Muscle anabolism after endurance exercise with essential amino acid supplementation.
Dietary Supplement: Essential Amino Acids
10 Gram Essential Amino Acid solutions with different leucine contents consumed during two identical endurance exercise trials
60 minute endurance exercise session
Change in muscle protein synthesis after exercise or exercise with amino acid supplementation.
Time frame: An average change over a 210 minute recovery period from a 60 minute endurance exercise session
Change in intracellular signaling after exercise or exercise with amino acid supplementation.
Time frame: At 30 minutes and 210 minutes after a 60 minute endurance exercise session
This study is completed, as verified in Jun 2011. You cannot join it, but the record below documents what was studied.
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United States Army Research Institute of Environmental Medicine