An interventional study of Protein Blend in Muscle Synthesis, sponsored by DuPont Nutrition and Health. Completed at 1 site in United States. Open to participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2019-10-07.
Sponsored by DuPont Nutrition and Health · Not applicable, Interventional, and Basic science
Soy protein is a high quality, plant-based protein that is comparable to milk, meat and eggs. Soy protein has a digestion rate (intermediate) compared to whey (fast) and casein (slow). This intermediate rate may allow soy protein to have an extended window of muscle protein synthesis that has not been monitored in previous studies. While most of the sports nutrition "recovery" products are dairy-based protein blends (high in branched-chain amino acids), soy protein offers additional benefits that can make an important contribution to these types of sports nutrition products. Soy protein contains approximately 300% more arginine and 30% more glutamine compared to whey protein and these two amino acids may bring additional benefits (immunity and hydration, respectively) to athletes. A "blend" of high-quality proteins (soy and dairy) may be the optimal sports nutrition product for athletes to consume following training.
DuPont Nutrition and Health is the lead sponsor of 6 studies on the registry; none are open to participants now.
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Exclusion criteria will be:
Other: Protein Blend
Other: Protein Blend
Single intake of approximately 20 grams of total protein
Muscle Protein Synthesis or Fractional synthesis rate (FSR)
The fractional synthesis rate (FSR) of mixed muscle proteins will be calculated from the incorporation rate of L-\[ring-13C6\]Phenylalanine into the mixed muscle proteins, and the free-tissue phenylalanine enrichment.
Time frame: baseline, 3 hours, 5 hours
oxidative and inflammatory markers
Proteins will be assessed that are markers of oxidative damage and inflammation (NFkB, IL-1, IL-6) and proteolysis (MuRF, MAFBx).
Time frame: baseline, 3 hours, 5 hours
Phosphorylation of protein in muscle protein signaling pathways
Phosphorylation of mTOR, 4E-BP1, S6K1, S6, and eEF2 will be measured using Western blot techniques as previously described.
Time frame: baseline, 3 hours, 5 hours
This study is completed, as verified in Oct 2019. You cannot join it, but the record below documents what was studied.
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DuPont Nutrition and Health