An interventional study of balanced solutions and not balanced in Large Bowel Cancer, sponsored by Università degli Studi di Ferrara. Completed at 1 site in Italy. Open to participants aged 18 Years to 90 Years. Per ClinicalTrials.gov, last updated 2017-05-08.
Sponsored by Università degli Studi di Ferrara · Not applicable, Interventional, and Treatment
Aim of the study is to ascertain whether a different strategy of fluids administration can be responsible of differences in terms of acid/base disorders (Stewart approach), pro-inflammatory and inflammatory mediators. Hence two groups of patients will be treated either with not-balanced solutions (Normal Saline) or balanced solutions
Università degli Studi di Ferrara is the lead sponsor of 64 studies on the registry; 10 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Emergency surgery for bowel punch or intestinal occlusion
arm in which the subjects received only balanced solutions
Behavioral: balanced solutions
arm in which the subjects received only not balanced solutions that means only normal saline and colloid dissolved in normal saline
Behavioral: not balanced
during the general anaesthesia until 8 o'clock of the day after the operation the subject will receive only balanced fluids that means balanced crystalloid and colloids dissolved in balanced solution. 12 ml /Kg/h during operation time. ratio 3:1 between crystalloid and colloid.
Also known as: sterofundin, tetraspan
during the operation time until the 8 o'clock of the day after the operation, the subjects will receive only normal saline and colloid dissolved in normal saline.
Also known as: Normal saline, Amidolite
acid/base disorder
the investigators assess difference in acid base disorders between the two groups measuring emogas analyses data and blood electrolites levels at the same time (two days)
Time frame: T0: anaesthesia induction (control value) T1: end of surgery T2: 1h after the end of surgery T3: 24h after the beginning of surgery
pro/antiinflammatory cytokine
-MMP-9 total and active, TIMP-1, IL-6, IL-8, IL-10, mieloperossidasis, ROS, MCP-3 will be measured during the observation period. (two days)
Time frame: T0: anaesthesia induction (control value) T1:end of surgery T2: 1h after the end of surgery T3: 24h after the beginning of surgery
This study is completed, as verified in May 2017. You cannot join it, but the record below documents what was studied.
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Università degli Studi di Ferrara